“Polyamine oxidase”的意思、由来-开放百科全书

词条

Polyamine oxidase

释义

Structural studies
References

{{enzyme
| Name = polyamine oxidase
| EC_number = 1.5.3.11
| CAS_number = 294646-71-2
| IUBMB_EC_number = 1/5/3/11
| GO_code = 0046592
| image =
| width =
| caption =
}}

In enzymology, a polyamine oxidase ({{EC number|1.5.3.11}}) is an enzyme that catalyzes the chemical reaction

N₁-acetylspermine + O₂ + H₂O N₁-acetylspermidine + 3-aminopropanal + H₂O₂

The 3 substrates of this enzyme are N1-acetylspermine, O₂, and H₂O, whereas its 3 products are N1-acetylspermidine, 3-aminopropanal, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N1-acetylspermidine:oxygen oxidoreductase (deaminating). This enzyme is also called 1-N-acetylspermidine:oxygen oxidoreductase (deaminating). It has 2 cofactors: FAD, and Iron. A similar enzyme in plants catalyzes non-acetylated polyamines.^[1]

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1B37}}, {{PDB link|1H81}}, {{PDB link|1H82}}, {{PDB link|1H83}}, {{PDB link|1H84}}, {{PDB link|1H86}}, {{PDB link|1RSG}}, {{PDB link|1YY5}}, and {{PDB link|1Z6L}}.

References

1. ^{{cite journal|last=Moschou|first=Panagiotis|author2=Maite Sanmartin |author3=Athina H Andriopoulou |author4=Enrique Rojo |author5=Jose J Sanchez-Serrano |author6=Kalliopi A Roubelakis-Angelakis |title=Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis|journal=Plant Physiology|date=1 August 2008|volume=147|issue=4|pages=1845–1857}}

{{cite journal |vauthors=Bolkenius FN, Seiler N | year = 1981 | title = Acetylderivatives as intermediates in polyamine catabolism | journal = Int. J. Biochem. | volume = 13 | pages = 287–292 | pmid = 7215618 | doi = 10.1016/0020-711X(81)90080-X | issue = 3 }}
{{Cite book | author = Holtta E | year = 1983 | title = Polyamine oxidase (rat liver) | journal = Methods Enzymol. | volume = 94 | pages = 306–311 | pmid = 6621391 | doi = 10.1016/S0076-6879(83)94054-5 | series = Methods in Enzymology | isbn = 978-0-12-181994-1 }}

4 : EC 1.5.3|Flavin enzymes|Iron enzymes|Enzymes of known structure

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