“Polyenoic fatty acid isomerase”的意思、由来-开放百科全书

词条

Polyenoic fatty acid isomerase

释义

References

{{confusing|date=October 2018}}{{enzyme
| Name = Polyenoic fatty acid isomerase
| EC_number = 5.3.3.13
| CAS_number =
| IUBMB_EC_number = 5/3/3/13
| GO_code =
| image =
| width =
| caption =
}}

In enzymology, a polyenoic fatty acid isomerase ({{EC number|5.3.3.13}}) is an enzyme that catalyzes the chemical reaction

(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate (5Z,7E,9E,14Z,17Z)-icosapentaenoate

Hence, this enzyme has one substrate, (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate, and one product, (5Z,7E,9E,14Z,17Z)-icosapentaenoate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Delta8,11-Delta7,9-isomerase (trans-double-bond-forming). Other names in common use include PFI, eicosapentaenoate cis-Delta5,8,11,14,17-eicosapentaenoate, cis-Delta5-trans-Delta7,9-cis-Delta14,17 isomerase, (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,8-isomerase, (incorrect), (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,9-isomerase, and (trans-double-bond-forming).

References

{{cite journal | vauthors = Wise ML, Hamberg M, Gerwick WH | author3-link = William H. Gerwick | date = 1994 | title = Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina | journal = Biochemistry | volume = 33 | pages = 15223–32 | pmid = 7803384 | doi = 10.1021/bi00255a002 | issue = 51 }}
{{cite journal | vauthors = Wise ML, Soderstrom K, Murray TF, Gerwick WH | author4-link = William_H._Gerwick | date = 1996 | title = Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid | journal = Experientia | volume = 52 | pages = 88–92 | pmid = 8575565 | doi = 10.1007/BF01922423 | issue = 1 }}
{{cite journal | vauthors = Wise ML, Rossi J, Gerwick WH | author3-link = William_H._Gerwick | date = 1997 | title = Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina | journal = Biochemistry | volume = 36 | pages = 2985–92 | pmid = 9062129 | doi = 10.1021/bi962158v | issue = 10 }}
{{cite journal | vauthors = Zheng W, Wise ML, Wyrick A, Metz JG, Yuan L, Gerwick WH | author6-link = William H. Gerwick | date = 2002 | title = Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA | journal = Arch. Biochem. Biophys. | volume = 401 | pages = 11–20 | pmid = 12054482 | doi = 10.1016/S0003-9861(02)00002-4 | issue = 1 }}

2 : EC 5.3.3|Enzymes of unknown structure

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