“Precorrin-2 C20-methyltransferase”的意思、由来-开放百科全书

词条

Precorrin-2 C20-methyltransferase

释义

Structural studies
References

{{enzyme
| Name = precorrin-2 C20-methyltransferase
| EC_number = 2.1.1.130
| CAS_number =
| IUBMB_EC_number = 2/1/1/130
| GO_code = 0030788
| image =
| width =
| caption =
}}

In enzymology, a precorrin-2 C20-methyltransferase ({{EC number|2.1.1.130}}) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + precorrin-2 S-adenosyl-L-homocysteine + precorrin-3A

Thus, the two substrates of this enzyme are S-adenosyl methionine and precorrin 2, whereas its two products are S-adenosylhomocysteine and precorrin 3A.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase. This enzyme participates in porphyrin and chlorophyll metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2E0K}} and {{PDB link|2E0N}}.

References

{{cite journal | vauthors = Stolowich NJ, Iida K, Scott AI | date = 1992 | title = Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis | journal = FEBS Lett. | volume = 301 | pages = 73–8 | pmid = 1451790 | doi = 10.1016/0014-5793(92)80213-Z | issue = 1 }}
{{cite journal | vauthors = Anousis N, Stolowich NJ, Holderman MT, Scott AI | date = 1995 | title = Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes | journal = Protein. Expr. Purif. | volume = 6 | pages = 155–63 | pmid = 7606163 | doi = 10.1006/prep.1995.1019 | issue = 2 }}
{{cite journal | vauthors = Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F | date = 1993 | title = Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans | journal = J. Bacteriol. | volume = 175 | pages = 7430–40 | pmid = 8226690 | issue = 22 | pmc = 206888 }}

2 : EC 2.1.1|Enzymes of known structure

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