“Precorrin-2 dehydrogenase”的意思、由来-开放百科全书

词条

Precorrin-2 dehydrogenase

释义

References

{{Orphan|date=July 2011}}{{enzyme
| Name = precorrin-2 dehydrogenase
| EC_number = 1.3.1.76
| CAS_number =
| IUBMB_EC_number = 1/3/1/76
| GO_code = 0043115
| image =
| width =
| caption =
}}

In enzymology, a precorrin-2 dehydrogenase ({{EC number|1.3.1.76}}) is an enzyme that catalyzes the chemical reaction

precorrin-2 + NAD⁺ sirohydrochlorin + NADH + H⁺

Thus, the two substrates of this enzyme are precorrin 2 and NAD⁺, whereas its 3 products are sirohydrochlorin, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is precorrin-2:NAD+ oxidoreductase. Other names in common use include Met8p, SirC, and CysG. This enzyme participates in porphyrin and chlorophyll metabolism.

References

{{cite journal | author = Warren MJ | year = 2002 | title = The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase | journal = EMBO J. | volume = 21 | pages = 2068–75 | pmid = 11980703 | doi = 10.1093/emboj/21.9.2068 | last2 = Raux | first2 = E | last3 = Brindley | first3 = AA | last4 = Leech | first4 = HK | last5 = Wilson | first5 = KS | last6 = Hill | first6 = CP | last7 = Warren | first7 = MJ | issue = 9 | pmc = 125995 }}
{{cite journal | vauthors = Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | year = 2002 | title = The biosynthesis of adenosylcobalamin (vitamin B12) | journal = Nat. Prod. Rep. | volume = 19 | pages = 390–412 | pmid = 12195810 | doi = 10.1039/b108967f | issue = 4 }}

3 : EC 1.3.1|NADH-dependent enzymes|Enzymes of unknown structure

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