“Precorrin-3B synthase”的意思、由来-开放百科全书

词条

Precorrin-3B synthase

释义

References

{{enzyme
| Name = precorrin-3B synthase
| EC_number = 1.14.13.83
| CAS_number =
| IUBMB_EC_number = 1/14/13/83
| GO_code = 0043818
| image =
| width =
| caption =
}}

In enzymology, a precorrin-3B synthase ({{EC number|1.14.13.83}}) is an enzyme that catalyzes the chemical reaction

precorrin-3A + NADH + H⁺ + O₂ precorrin-3B + NAD⁺ + H₂O

The 4 substrates of this enzyme are precorrin 3A, NADH, H⁺, and O₂, whereas its 3 products are precorrin 3B, NAD⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating). Other names in common use include precorrin-3X synthase, and CobG. This enzyme participates in porphyrin and chlorophyll metabolism.

References

{{cite journal | vauthors = Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F | date = 1993 | title = Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans | journal = J. Bacteriol. | volume = 175 | pages = 7430–40 | pmid = 8226690 | issue = 22 | pmc = 206888 }}
{{cite journal | vauthors = Scott AI, Roessner CA, Stolowich NJ, Spencer JB, Min C, Ozaki SI | date = 1993 | title = Biosynthesis of vitamin B12. Discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group | journal = FEBS Lett. | volume = 331 | pages = 105–8 | pmid = 8405386 | doi = 10.1016/0014-5793(93)80306-F | issue = 1-2 }}
{{cite journal | vauthors = Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | date = 2002 | title = The biosynthesis of adenosylcobalamin (vitamin B12) | journal = Nat. Prod. Rep. | volume = 19 | pages = 390–412 | pmid = 12195810 | doi = 10.1039/b108967f | issue = 4 }}

4 : EC 1.14.13|NADPH-dependent enzymes|NADH-dependent enzymes|Enzymes of unknown structure

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