“Precorrin-6A reductase”的意思、由来-开放百科全书

词条

Precorrin-6A reductase

释义

References

{{enzyme
| Name = precorrin-6A reductase
| EC_number = 1.3.1.54
| CAS_number = 137672-84-5
| IUBMB_EC_number = 1/3/1/54
| GO_code = 0016994
| image =
| width =
| caption =
}}

In enzymology, a precorrin-6A reductase ({{EC number|1.3.1.54}}) is an enzyme that catalyzes the chemical reaction

precorrin-6B + NADP⁺ precorrin-6A + NADPH + H⁺

Thus, the two substrates of this enzyme are precorrin 6B and NADP⁺, whereas its 3 products are precorrin 6A, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is precorrin-6B:NADP+ oxidoreductase. Other names in common use include precorrin-6X reductase, and precorrin-6Y:NADP+ oxidoreductase. This enzyme participates in porphyrin and chlorophyll metabolism.

References

{{cite journal | vauthors = Blanche F, Thibaut D, Famechon A, Debussche L, Cameron B, Crouzet J | date = 1992 | title = Precorrin-6x reductase from Pseudomonas denitrificans: purification and characterization of the enzyme and identification of the structural gene | journal = J. Bacteriol. | volume = 174 | pages = 1036–42 | pmid = 1732193 | issue = 3 | pmc = 206185 }}
{{cite journal | vauthors = Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | date = 2002 | title = The biosynthesis of adenosylcobalamin (vitamin B12) | journal = Nat. Prod. Rep. | volume = 19 | pages = 390–412 | pmid = 12195810 | doi = 10.1039/b108967f | issue = 4 }}

3 : EC 1.3.1|NADPH-dependent enzymes|Enzymes of unknown structure

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