“Precorrin-6A synthase (deacetylating)”的意思、由来-开放百科全书

词条

Precorrin-6A synthase (deacetylating)

释义

References

{{enzyme
| Name = precorrin-6A synthase (deacetylating)
| EC_number = 2.1.1.152
| CAS_number =
| IUBMB_EC_number = 2/1/1/152
| GO_code = 0043819
| image =
| width =
| caption =
}}

In enzymology, a precorrin-6A synthase (deacetylating) ({{EC number|2.1.1.152}}) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + precorrin-5 + H₂O S-adenosyl-L-homocysteine + precorrin-6A + acetate

The 3 substrates of this enzyme are S-adenosyl methionine, precorrin 5, and H₂O, whereas its 3 products are S-adenosylhomocysteine, precorrin 6A, and acetate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating). Other names in common use include precorrin-6X synthase (deacetylating), and CobF. This enzyme participates in porphyrin and chlorophyll metabolism.

References

{{cite journal |vauthors=Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F | date = 1993 | title = Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans | journal = J. Bacteriol. | volume = 175 | pages = 7430–40 | pmid = 8226690 | issue = 22 | pmc = 206888 }}
{{cite journal |vauthors=Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | date = 2002 | title = The biosynthesis of adenosylcobalamin (vitamin B12) | journal = Nat. Prod. Rep. | volume = 19 | pages = 390–412 | pmid = 12195810 | doi = 10.1039/b108967f | issue = 4 }}

2 : EC 2.1.1|Enzymes of unknown structure

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