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词条 Prenoxdiazine
释义

  1. References

{{Drugbox
| verifiedrevid = 464214020
| IUPAC_name = 1-[2-[3-(2,2-diphenylethyl)-1,2,4-oxadiazol-5-yl]ethyl]piperidine
| image = Prenoxdiazine.png
| tradename = Libexin
| Drugs.com = {{drugs.com|international|prenoxdiazine}}
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration =
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 982-43-4
| ATC_prefix = R05
| ATC_suffix = DB18
| PubChem = 120508
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 107586
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = S491HH391H
| C=23 | H=27 | N=3 | O=1
| molecular_weight = 361.48 g/mol
| smiles = n1c(onc1CC(c2ccccc2)c3ccccc3)CCN4CCCCC4
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C23H27N3O/c1-4-10-19(11-5-1)21(20-12-6-2-7-13-20)18-22-24-23(27-25-22)14-17-26-15-8-3-9-16-26/h1-2,4-7,10-13,21H,3,8-9,14-18H2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = PXZDWASDNFWKSD-UHFFFAOYSA-N
}}

Prenoxdiazine (marketed as Libexin) is a cough suppressant.[1] It acts peripherally by desensitizing the pulmonary stretch receptors. Therefore there's a reduction of cough impulses originating in the lungs. Prenoxdiazine is indicated in cough of bronchial origin.

References

1. ^{{Cite journal | last1 = Csürös | first1 = L. | title = Fifteen years of experience on the use of Libexin tablets | journal = Therapia Hungarica (English edition) | volume = 37 | issue = 1 | pages = 50–54 | year = 1989 | pmid = 2667194}}
{{Cough and cold preparations}}{{respiratory-system-drug-stub}}

3 : Antitussives|Piperidines|Oxadiazoles

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