1. Pre-embryo in human embryonic development

2. Ontological status

3. See also

4. Footnotes

Pre-embryo in human embryonic development

The word 'pre-embryo' sometimes is used in ethical contexts to refer a human conceptus at least between fertilization and implantation, and is known too as a proembryo although this is not term which has been adopted by the scientific community.^[4] A conceptus between fertilization and implantation is also frequently classified as an embryo.^[3]

Even after implantation begins, a preembryo (and proembryo) may exist up until formation of the primitive streak.^[4] Implantation begins at about six days after fertilization, and lasts for about a week, during which time formation of the primitive streak occurs.^[5]

Use of the terms preembryo and proembryo, in the context of human development, has drawn criticism from opponents of embryo research, and from scientists who have considered this categorization invalid or unnecessary.^[6][7][8] One rationale that has been advanced for distinguishing an early fertilized human conceptus from an embryo is that there is a potential for the conceptus to split into identical twins prior to implantation, and so (the argument goes) the conceptus cannot be regarded before implantation as a single human being. However, the conceptus before implantation exhibits self-actuated activity, which has led to the assertion that it is an embryo.^[9] Further, identical twinning is an instance of asexual reproduction whereby a conceptus, without ceasing to be what it is (a new human being), provides a cell or cells as a new conceptus, entirely separated or partially separated (a 'siamese' twin) from the original conceptus, but in any event self-actuated in its development from the moment that the act of asexual reproduction (twinning) is complete. By this asexual reproduction, the parents of the original conceptus in effect become grandparents to the identical twin so conceived.

In the United States, a report by the National Institutes of Health stated that a conceptus could be both a pre-implantation embryo and a pre-embryo at the same time.^[10] However, Ann Kiessling (a leader in stem cell research) has written that those categories are inaccurate.^[11]

Ontological status

The illustration shows the ontological status of the preembryo, embryo, and fetus:

• (o) indicates the (natural &) standard reproductive and embryogenic pathway
• (mz) indicates all the possible pathways for a monozygotic twin {{small|(see Scott, 2002, Hall, 2003, for a review on monozygotic twinning)}}
• (/c) indicates a clone created by either SCNT or ANT {{small|(See Hurlbut, 2005, and section III. Pluripotent Stem Cells Derived from Biological Artifacts in the PCBE's Report on alternative sources of stem cells for a review of ANT))}}
• (ch) indicates all the possible pathways for a chimeric individual {{small|(see Charles E. Boklage, 2006, for a review on chimerism and twinning)}}
• (dz) indicates the pathway of a dizygotic twin
• (en) indicates an enucleated oocyte
• (m) indicates a hydatidiform mole
• (cm) indicates a complete hydatidiform mole
• (pm) indicates a partial hydatidiform mole, and
• (p) indicates parthenogenesis.

• (O) indicates an oocyte,
• (Z) indicates a zygote,
• (M) indicates a morula,
• (B) indicates a blastocyst,
• (E) indicates an embryo,
• (F) indicates a fetus,
• (I) indicates a live born individual person.
• (PM) indicates a partial hydatidiform mole,
• (CM) indicates a complete hydatidiform mole,
• (T) indicates a teratoma.

The colors represent the maternal and paternal genetic contributions.

See also

• Beginning of pregnancy controversy
• In vitro fertilization
• Pregnancy
• Stem cell controversy

Footnotes

• The Glory Day
• The Glory of Christmas
• The Glory of Solomon
• The Glory of their times
• The glory of their times
• The Glory of their Times
• The Glory That Was
• The Glossary of Meteorology
• The Glosters
• The Gloucestershire Regiment
• The glove
• The Glove (Courage The Cowardly Dog)
• The Glove (film)
• The Glow, Pt. 2
• The Glow Pt. 2
• The Glow-Worm
• The Glow Worm
• The Glowworm
• The Glugs of Gosh
• The Glutton Bowl
• The Glyn Hopkin Stadium
• The Gman
• The G-Man
• The G Man
• The GM Cup