| 词条 | Proglumetacin |
| 释义 |
| Watchedfields = changed | verifiedrevid = 443950501 | IUPAC_name = 3- | image = Proglumetacin.svg | tradename = | Drugs.com = {{drugs.com|international|proglumetacin}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = Hepatic. Undergoes enterohepatic recirculation | elimination_half-life = | excretion = | CAS_number = 57132-53-3 | CAS_supplemental = {{CAS|59209-40-4}} | ATC_prefix = M01 | ATC_suffix = AB14 | PubChem = 4921 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4752 | ChEBI = 76263 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = FV919079LU | C=46 | H=58 | Cl=1 | N=5 | O=8 | molecular_weight = 844.43442 g/mol | smiles = Clc1ccc(cc1)C(=O)n3c2ccc(OC)cc2c(c3C)CC(=O)OCCN4CCN(CC4)CCCOC(=O)CCC(C(=O)N(CCC)CCC)NC(=O)c5ccccc5 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = PTXGHCGBYMQQIG-UHFFFAOYSA-N | synonyms = 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate }} Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a nonsteroidal anti-inflammatory drug (NSAID). It is metabolized in the body to indometacin and proglumide,[1] a drug with antisecretory effects that helps prevent injury to the stomach lining. References1. ^{{cite journal |vauthors=Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L |title=Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog |journal=Arzneimittel-Forschung |volume=37 |issue=6 |pages=698–702 |year=1987 |pmid=3663267 |doi=}} {{Anti-inflammatory and antirheumatic products}}{{Prostanoidergics}}{{musculoskeletal-drug-stub}} 7 : Nonsteroidal anti-inflammatory drugs|Prodrugs|Indoles|Phenol ethers|Piperazines|Carboxylate esters|Benzamides |
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