“Propanediol dehydratase”的意思、由来-开放百科全书

词条

Propanediol dehydratase

释义

Structural studies
References

{{enzyme
| Name = propanediol dehydratase
| EC_number = 4.2.1.28
| CAS_number = 9026-90-8
| IUBMB_EC_number = 4/2/1/28
| GO_code = 0050215
| image =
| width =
| caption =
}}

In enzymology, a propanediol dehydratase ({{EC number|4.2.1.28}}) is an enzyme that catalyzes the chemical reaction

propane-1,2-diol propanal + H₂O

Hence, this enzyme has one substrate, 1,2-propanediol, and two products, propanal and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is propane-1,2-diol hydro-lyase (propanal-forming). Other names in common use include meso-2,3-butanediol dehydrase, diol dehydratase, DL-1,2-propanediol hydro-lyase, diol dehydrase, adenosylcobalamin-dependent diol dehydratase, propanediol dehydrase, coenzyme B₁₂-dependent diol dehydrase, 1,2-propanediol dehydratase, dioldehydratase, and propane-1,2-diol hydro-lyase. This enzyme participates in glycerolipid metabolism. It employs one cofactor, cobamide.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1DIO}}, {{PDB link|1EEX}}, {{PDB link|1EGM}}, {{PDB link|1EGV}}, {{PDB link|1IWB}}, {{PDB link|1UC4}}, and {{PDB link|1UC5}}.

References

{{cite journal | vauthors = ABELES RH, LEE HA | date = 1961 | title = An intramolecular oxidation-reduction requiring a cobamide coenzyme | journal = J. Biol. Chem. | volume = 236 | pages = 2347–50 | pmid = 13680987 }}
{{cite journal | vauthors = Forage RG, Foster MA | date = 1982 | title = Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases | journal = J. Bacteriol. | volume = 149 | pages = 413–9 | pmid = 7035429 | issue = 2 | pmc = 216523 }}
{{cite journal | vauthors = LEE HA, ABELES RH | date = 1963 | title = Purification and properties of dioldehydrase, and enzyme requiring a cobamide coenzyme | journal = J. Biol. Chem. | volume = 238 | pages = 2367–73 | pmid = 13929077 }}

3 : EC 4.2.1|Cobamide enzymes|Enzymes of known structure

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