| 词条 | Proquazone |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 376116641 | IUPAC_name = 1-isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one | image = proquazone.png | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 22760-18-5 | ATC_prefix = M01 | ATC_suffix = AX13 | PubChem = 31508 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 42VPJ2980S | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 268501 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 29222 | C=18 | H=18 | N=2 | O=1 | molecular_weight = 278.34832 g/mol | smiles = CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=CC=C3 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = JTIGKVIOEQASGT-UHFFFAOYSA-N }}Proquazone is a nonsteroidal anti-inflammatory drug, known as a NSAID.[1] Synthesis[2][3]References1. ^{{Cite journal | doi = 10.2165/00003495-198733050-00004 | last1 = Clissold | first1 = S. P. | last2 = Beresford | first2 = R. | title = Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states | journal = Drugs | volume = 33 | issue = 5 | pages = 478–502 | year = 1987 | pmid = 3297621}} {{Anti-inflammatory and antirheumatic products}}{{musculoskeletal-drug-stub}}2. ^{{cite journal|last1=Coombs|first1=R. V.|last2=Danna|first2=R. P.|last3=Denzer|first3=M.|last4=Hardtmann|first4=G. E.|last5=Huegi|first5=B.|last6=Koletar|first6=G.|last7=Koletar|first7=J.|last8=Ott|first8=H.|last9=Jukniewicz|first9=E.|title=Synthesis and antiinflammatory activity of 1-alkyl-4-aryl-2(1H)-quinazolines and quinazolinethiones|journal=Journal of Medicinal Chemistry|volume=16|issue=11|year=1973|pages=1237–1245|issn=0022-2623|doi=10.1021/jm00269a006}} 3. ^G. Gamboni, W. Schmid and A. Sutter; GB1592687 (1981 to Sandoz). 2 : Quinazolinones|Ureas |
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