| 释义 |
- Function
- Nomenclature
- Pathways
- See also
- References
- Further reading
- External links
{{enzyme
| Name = prostaglandin-I synthase
| EC_number = 5.3.99.4
| CAS_number = 65802-86-0
| IUBMB_EC_number = 5/3/99/4
| GO_code = 0008116
| image = Prostacyclin synthase 2IAG Chiang et al.png
| width = 292px
| caption = Cartoon diagram of human prostacyclin synthase. Heme group visible at center. From {{PDB|2IAG}}
}}{{Infobox_gene}}Prostaglandin-I synthase ({{EC number|5.3.99.4}}) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene.[1] This enzyme belongs to the family of cytochrome P450 isomerases. Function This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.[2] Unlike most P450 enzymes, PGIS does not require molecular oxygen (O2). Instead it uses its heme cofactor to catalyze the isomerization of prostaglandin H2 to prostacyclin. Prostaglandin H2 is produced by cyclooxygenase in the first committed step of prostaglandin biosynthesis. Nomenclature The systematic name of this enzyme class is (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase. Other names in common use include prostacyclin synthase, prostacyclin synthetase, prostagladin I2 synthetase, PGI2 synthase, PGIS, PTGIS, and PGI2 synthetase. Pathways See alsoReferences1. ^{{cite journal |vauthors=Yokoyama C, Yabuki T, Inoue H, Tone Y, Hara S, Hatae T, Nagata M, Takahashi EI, Tanabe T | title = Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity | journal = Genomics | volume = 36 | issue = 2 | pages = 296–304 |date=September 1996 | pmid = 8812456 | doi = 10.1006/geno.1996.0465 | url = | issn = }}
2. ^{{cite web | title = Entrez Gene: PTGIS | url =https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5740 | accessdate = }}
Further reading {{refbegin|2}}- {{cite journal |vauthors=DeWitt DL, Smith WL | year = 1983 | title = Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein | journal = J. Biol. Chem. | volume = 258 | pages = 3285–93 | pmid = 6338016 | issue = 5 }}
- {{cite journal |vauthors=Ullrich V, Castle L, Weber P | year = 1981 | title = Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase | journal = Biochem. Pharmacol. | volume = 30 | pages = 2033–6 | pmid = 7023490 | doi = 10.1016/0006-2952(81)90218-5 | issue = 14 }}
- {{cite journal |vauthors=Xie X, Ma YT, Fu ZY, etal |title=[Study on the association of cyclooxygenase-2 -765g>C and prostacyclin synthase C1117A polymorphisms and the risk of myocardial infarction in Uigur population of Xinjiang, China] |journal=Zhonghua Liu Xing Bing Xue Za Zhi |volume=29 |issue= 6 |pages= 598–603 |year= 2008 |pmid= 19040046 |doi= }}
- {{cite journal |vauthors=Yoshida T, Kato K, Yokoi K, etal |title=Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. |journal=Int. J. Mol. Med. |volume=24 |issue= 2 |pages= 233–46 |year= 2009 |pmid= 19578796 |doi= 10.3892/ijmm_00000226}}
- {{cite journal |vauthors=Palmieri RT, Wilson MA, Iversen ES, etal |title=Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=17 |issue= 12 |pages= 3567–72 |year= 2008 |pmid= 19064572 |doi= 10.1158/1055-9965.EPI-08-0548 |pmc=2664299 }}
- {{cite journal |vauthors=Mavaddat N, Dunning AM, Ponder BA, etal |title=Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=18 |issue= 1 |pages= 255–9 |year= 2009 |pmid= 19124506 |doi= 10.1158/1055-9965.EPI-08-0704 |pmc=2655077 }}
- {{cite journal |vauthors=Xie X, Ma YT, Fu ZY, etal |title=[Association of GLu461ALa polymorphism of prostacyclin synthase gene with myocardial infarction in Uigur population] |journal=Zhonghua Yu Fang Yi Xue Za Zhi |volume=43 |issue= 3 |pages= 237–41 |year= 2009 |pmid= 19534932 |doi= }}
- {{cite journal |vauthors=Yoshida T, Kato K, Fujimaki T, etal |title=Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. |journal=Genomics |volume=93 |issue= 3 |pages= 221–6 |year= 2009 |pmid= 19056482 |doi= 10.1016/j.ygeno.2008.11.001 }}
- {{cite journal |vauthors=Dagle JM, Lepp NT, Cooper ME, etal |title=Determination of genetic predisposition to patent ductus arteriosus in preterm infants. |journal=Pediatrics |volume=123 |issue= 4 |pages= 1116–23 |year= 2009 |pmid= 19336370 |doi= 10.1542/peds.2008-0313 |pmc=2734952 }}
- {{cite journal |vauthors=Xie X, Ma Y, Fu Z, etal |title=[Association of polymorphism of the prostacyclin synthase gene with myocardial infarction in Uigur population of Xinjiang] |journal=Zhonghua Yi Xue Yi Chuan Xue Za Zhi |volume=25 |issue= 6 |pages= 708–11 |year= 2008 |pmid= 19065539 |doi= }}
- {{cite journal |vauthors=Nelson DR, Zeldin DC, Hoffman SM, etal |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1–18 |year= 2004 |pmid= 15128046 |doi=10.1097/00008571-200401000-00001 }}
- {{cite journal |vauthors=Barbali M, Naranci NS, Skari-Juri T|title=A quantitative trait locus for SBP maps near KCNB1 and PTGIS in a population isolate. |journal=Am. J. Hypertens. |volume=22 |issue= 6 |pages= 663–8 |year= 2009 |pmid= 19265782 |doi= 10.1038/ajh.2009.46 |display-authors=etal}}
- {{cite journal |vauthors=Xie X, Ma YT, Fu ZY, etal |title=Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. |journal=Clin. Chem. Lab. Med. |volume=47 |issue= 3 |pages= 347–52 |year= 2009 |pmid= 19327107 |doi= 10.1515/CCLM.2009.078 }}
- {{cite journal |vauthors=Abraham JE, Harrington P, Driver KE, etal |title=Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. |journal=Clin. Cancer Res. |volume=15 |issue= 6 |pages= 2181–91 |year= 2009 |pmid= 19276290 |doi= 10.1158/1078-0432.CCR-08-0716 }}
- {{cite journal |vauthors=Ruan KH, Wu J, Cervantes V |title=Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. |journal=Biochemistry |volume=47 |issue= 2 |pages= 680–8 |year= 2008 |pmid= 18081314 |doi= 10.1021/bi701671q }}
- {{cite journal |vauthors=Hashimoto K, Ishibashi K, Gebretsadik T, etal |title=Functional polymorphism of the promoter region of the prostacyclin synthase gene and severity of RSV infection in hospitalized children. |journal=J. Med. Virol. |volume=80 |issue= 11 |pages= 2015–22 |year= 2008 |pmid= 18814254 |doi= 10.1002/jmv.21318 }}
- {{cite journal |author1=Xiang Xie |author2=Ma YT |author3=Fu ZY |title=Haplotype analysis of the CYP8A1 gene associated with myocardial infarction. |journal=Clin. Appl. Thromb. Hemost. |volume=15 |issue= 5 |pages= 574–80 |year= 2009 |pmid= 19147528 |doi= 10.1177/1076029608329581 |display-authors=etal}}
- {{cite journal |vauthors=Lemaitre RN, Rice K, Marciante K, etal |title=Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. |journal=Atherosclerosis |volume=204 |issue= 2 |pages= e58–63 |year= 2009 |pmid= 19046748 |doi= 10.1016/j.atherosclerosis.2008.10.011 |pmc=2753183 }}
- {{cite journal |vauthors=Ito T, Okada T, Mimuro J, etal |title=Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats. |journal=Hypertension |volume=50 |issue= 3 |pages= 531–6 |year= 2007 |pmid= 17635855 |doi= 10.1161/HYPERTENSIONAHA.107.091348 }}
- {{cite journal |vauthors=Ma YT, Xie X, Fu ZY, etal |title=[Haplotypes analysis of the prostacyclin synthase gene and myocardial infarction in Uigur population] |journal=Zhonghua Xin Xue Guan Bing Za Zhi |volume=37 |issue= 2 |pages= 115–9 |year= 2009 |pmid= 19719985 |doi= }}
- {{cite journal |vauthors=Yeh HC, Gerfen GJ, Wang JS, etal |title=Characterization of the peroxidase mechanism upon reaction of prostacyclin synthase with peracetic acid. Identification of a tyrosyl radical intermediate. |journal=Biochemistry |volume=48 |issue= 5 |pages= 917–28 |year= 2009 |pmid= 19187034 |doi= 10.1021/bi801382v |pmc=2849756 }}
- {{cite journal |vauthors=Young RP, Hopkins RJ, Hay BA, etal |title=A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. |journal=Postgrad Med J |volume=85 |issue= 1008 |pages= 515–24 |year= 2009 |pmid= 19789190 |doi= 10.1136/pgmj.2008.077107 }}
{{refend}}External links- {{MeshName|prostacyclin+synthetase}}
{{NLM content}}{{Cytochrome P450}}{{Metabolism of complex lipids}}{{Prostanoid signaling modulators}}{{Intramolecular oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}} 3 : EC 5.3.99|Heme enzymes|Enzymes of known structure |