“Prostaglandin-E2 9-reductase”的意思、由来-开放百科全书

词条

Prostaglandin-E2 9-reductase

释义

Structural studies
References

{{DISPLAYTITLE:Prostaglandin-E₂ 9-reductase}}{{enzyme
| Name = prostaglandin-E₂ 9-reductase
| EC_number = 1.1.1.189
| CAS_number = 42613-35-4
| IUBMB_EC_number = 1/1/1/189
| GO_code = 0050221
| image =
| width =
| caption =
}}

In enzymology, a prostaglandin-E₂ 9-reductase ({{EC number|1.1.1.189}}) is an enzyme that catalyzes the chemical reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP⁺ (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H⁺

Thus, the two substrates of this enzyme are (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate and NADP⁺, whereas its 3 products are (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP⁺ 9-oxidoreductase. Other names in common use include PGE₂-9-OR, reductase, 15-hydroxy-9-oxoprostaglandin, 9-keto-prostaglandin E₂ reductase, 9-ketoprostaglandin reductase, PGE-9-ketoreductase, PGE₂ 9-oxoreductase, PGE₂ reductase-9-ketoreductase, prostaglandin 9-ketoreductase, prostaglandin E 9-ketoreductase, and prostaglandin E₂ reductase-9-oxoreductase. This enzyme participates in arachidonic acid metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1Q13}}, {{PDB link|1Q5M}}, and {{PDB link|2PFG}}.

References

{{cite journal | vauthors = Lee SC, Levine L | year = 1975 | title = Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase | journal = J. Biol. Chem. | volume = 250 | pages = 4549–55 | pmid = 166995 | issue = 12 }}
{{cite journal | vauthors = Schlegel W, Kruger S, Korte K | year = 1984 | title = Purification of prostaglandin E₂ reductase-9-oxoreductase from human decidua vera | journal = FEBS Lett. | volume = 171 | pages = 141–4 | pmid = 6586494 | doi = 10.1016/0014-5793(84)80475-5 | issue = 1 }}
{{cite journal | vauthors = Tai HH, Yuan B | year = 1982 | title = Purification and assay of 9-hydroxyprostaglandin dehydrogenase from rat kidney | journal = Methods Enzymol. | volume = 86 | pages = 113–7 | pmid = 7132747 | doi = 10.1016/0076-6879(82)86178-8 }}
{{cite journal | vauthors = Watkins JD, Jarabak J | year = 1985 | title = The effect of NaCl intake on 9-ketoprostaglandin reductase activity in the rabbit kidney | journal = Prostaglandins | volume = 30 | pages = 335–49 | pmid = 3901124 | doi = 10.1016/0090-6980(85)90196-0 | issue = 2 }}

{{Eicosanoid metabolism enzymes}}{{Prostanoidergics}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{1.1.1-enzyme-stub}}

3 : EC 1.1.1|NADPH-dependent enzymes|Enzymes of known structure

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