“Prostaglandin-F synthase”的意思、由来-开放百科全书

词条

Prostaglandin-F synthase

释义

Structural studies
References

{{enzyme
| Name = prostaglandin-F synthase
| EC_number = 1.1.1.188
| CAS_number = 55976-95-9
| IUBMB_EC_number = 1/1/1/188
| GO_code = 0047017
| image =
| width =
| caption =
}}

In enzymology, a prostaglandin-F synthase ({{EC number|1.1.1.188}}) is an enzyme that catalyzes the chemical reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP⁺ (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H⁺

Thus, the two substrates of this enzyme are (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate and NADP⁺, whereas its 3 products are (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP⁺ 11-oxidoreductase. Other names in common use include prostaglandin-D₂ 11-reductase, reductase, 15-hydroxy-11-oxoprostaglandin, PGD₂ 11-ketoreductase, PGF_2α synthetase, prostaglandin 11-ketoreductase, prostaglandin D₂-ketoreductase, prostaglandin F synthase, prostaglandin F synthetase, synthetase, prostaglandin F_2α, prostaglandin-D₂ 11-reductase, PGF synthetase, NADPH-dependent prostaglandin D₂ 11-keto reductase, and prostaglandin 11-keto reductase. This enzyme participates in arachidonic acid metabolism.

Structural studies

{{As of|2007|alt=As of late 2007}}, 7 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1RY0}}, {{PDB link|1RY8}}, {{PDB link|1VBJ}}, {{PDB link|1XF0}}, {{PDB link|1ZQ5}}, {{PDB link|2F38}}, and {{PDB link|2FGB}}.

References

{{cite journal | vauthors = Reingold DF, Kawasaki A, Needleman P | date = 1981 | title = A novel prostaglandin 11-keto reductase found in rabbit liver | journal = Biochim. Biophys. Acta | volume = 659 | pages = 179–88 | pmid = 7248318 | issue = 1 | doi=10.1016/0005-2744(81)90282-5}}
{{cite journal | vauthors = Watanabe K, Shimizu T, Hayaishi O | date = 1981 | title = Enzymatic conversion of prostaglandin-D₂ to prostaglandin-F_2α in the rat lung | journal = Biochem. Int. | volume = 2 | pages = 603–610 }}
{{cite journal | vauthors = Watanabe K, Yoshida R, Shimizu T, Hayaishi O | date = 1985 | title = Enzymatic formation of prostaglandin F_2α from prostaglandin H₂ and D₂. Purification and properties of prostaglandin F synthetase from bovine lung | journal = J. Biol. Chem. | volume = 260 | pages = 7035–41 | pmid = 3858278 | issue = 11 }}
{{cite journal | author = Wong PY | date = 1981 | title = Purification and partial characterization of prostaglandin D₂ 11-keto reductase in rabbit liver | journal = Biochim. Biophys. Acta | volume = 659 | pages = 169–78 | pmid = 7248317 | issue = 1 | doi = 10.1016/0005-2744(81)90281-3 }}
{{cite journal | author = Wong PY | date = 1982 | title = Purification of PGD₂ 11-ketoreductase from rabbit liver | journal = Methods Enzymol. | volume = 86 | pages = 117–25 | pmid = 7132748 | doi = 10.1016/0076-6879(82)86179-X }}

4 : Prostaglandins|EC 1.1.1|NADPH-dependent enzymes|Enzymes of known structure

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