“Protein-disulfide reductase”的意思、由来-开放百科全书

词条

Protein-disulfide reductase

释义

Structural studies
References

{{enzyme
| Name = protein-disulfide reductase
| EC_number = 1.8.1.8
| CAS_number = 9029-19-0
| IUBMB_EC_number = 1/8/1/8
| GO_code = 0047134
| image =
| width =
| caption =
}}

In enzymology, a protein-disulfide reductase ({{EC number|1.8.1.8}}) is an enzyme that catalyzes the chemical reaction

protein dithiol + NAD(P)+ protein disulfide + NAD(P)H + H⁺

The 3 substrates of this enzyme are protein dithiol, NAD⁺, and NADP⁺, whereas its 4 products are protein disulfide, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is protein-dithiol:NAD(P)+ oxidoreductase. Other names in common use include protein disulphide reductase, insulin-glutathione transhydrogenase, disulfide reductase, and NAD(P)H2:protein-disulfide oxidoreductase.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1UC7}}, {{PDB link|1VRS}}, {{PDB link|1Z5Y}}, {{PDB link|2FWE}}, {{PDB link|2FWF}}, {{PDB link|2FWG}}, {{PDB link|2FWH}}, and {{PDB link|2PPT}}.

References

{{cite journal |vauthors=HATCH MD, TURNER JF | date = 1960 | title = A protein disulphide reductase from pea seeds | journal = Biochem. J. | volume = 76 | pages = 556–62 | pmid = 13712218 | pmc = 1204833 | issue = 3 }}

4 : EC 1.8.1|NADPH-dependent enzymes|NADH-dependent enzymes|Enzymes of known structure

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