| 词条 | Proxibarbital |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 464375627 | IUPAC_name = (RS)-5-allyl-5-(2-hydroxypropyl)pyrimidine-2,4,6(1H,3H,5H)-trione | image = Proxibarbital.svg | width = 120 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 2537-29-3 | ATC_prefix = N05 | ATC_suffix = CA22 | PubChem = 17336 | ChEMBL = 2105233 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 16406 | C=10 | H=14 | N=2 | O=4 | molecular_weight = 226.229 g/mol | smiles = O=C1NC(=O)NC(=O)C1(CC(O)C)C\\C=C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C10H14N2O4/c1-3-4-10(5-6(2)13)7(14)11-9(16)12-8(10)15/h3,6,13H,1,4-5H2,2H3,(H2,11,12,14,15,16) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = VNLMRPAWAMPLNZ-UHFFFAOYSA-N | synonyms = Proxibarbital, Centralgol, Ipronal, 5-Allyl-5-(β-hydroxypropyl)barbituric acid }}Proxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956. It has anti-anxiety properties and in contrast to most barbiturates almost without hypnotic action.[1] It was also used in the treatment of migraine headaches in a similar manner to butalbital.[2] Valofane isomerises to Proxibarbal in vivo. References1. ^{{cite book| editor1-last = Zejc | editor1-first = A.| editor2-last = Gorczyca | editor2-first = M.| last1 = Zajdel | first1 = P.| last2 = Kulig | first2 = K.| last3 = Zejc | first3 = A.| title = Chemia leków, podręcznik dla studentów farmacji i farmaceutów | language = polish | year = 2008| location = Warszawa, Poland| isbn = 978-83-200-3652-7}} {{Hypnotics and sedatives}}{{GABAAR PAMs}}{{sedative-stub}}2. ^{{Cite journal | last1 = Sulman | first1 = F. G. | last2 = Pfeifer | first2 = Y. | last3 = Tal | first3 = E. | title = Migraine therapy by enzyme induction with proxibarbital | journal = Therapie der Gegenwart | language = german| volume = 115 | issue = 12 | pages = 2088–2103 | year = 1976 | pmid = 14412}} 4 : Barbiturates|Antimigraine drugs|Allyl compounds|GABAA receptor positive allosteric modulators |
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