| 词条 | PyBOP |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 464376527 | ImageFile = PyBOP.svg | ImageSize = 240px | ImageFile1 = PyBOP ions ball.png | ImageSize1 = 240 | ImageAlt1 = Ball-and-stick model of the component ions of PyBOP | IUPACName = (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate | OtherNames = PyBOP |Section1={{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2006820 | InChI = 1/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1 | InChIKey = VIAFLMPQBHAMLI-UHFFFAOYAY | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = VIAFLMPQBHAMLI-UHFFFAOYSA-N | CASNo_Ref = {{cascite|changed|??}} | CASNo = 128625-52-5 | PubChem = 2724699 | SMILES = F[P-](F)(F)(F)(F)F.n4nn(O[P+](N1CCCC1)(N2CCCC2)N3CCCC3)c5ccccc45 }} |Section2={{Chembox Properties | C=18 | H=28 | N=6 | O=1 | P=2 | F=6 | Appearance = White crystals | Density = | MeltingPtC = 150 | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = Irritant | FlashPt = | AutoignitionPt = | RPhrases = {{R36/37/38}} | SPhrases = {{S26}}-{{S36}} }}PyBOP (benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) is a peptide coupling reagent used in solid phase peptide synthesis. It is used as a substitute for the BOP reagent - avoiding the formation of the carcinogenic waste product HMPA.[1] It has also been used for the licit and illicit production of LSD from lysergic acid and diethylmethylamine [2] See also
References1. ^{{Cite journal | doi = 10.1016/S0040-4039(00)94371-5 | title = PyBOP®: A new peptide coupling reagent devoid of toxic by-product | year = 1990 | last1 = Coste | first1 = J. | last2 = Le-Nguyen | first2 = D. | last3 = Castro | first3 = B. | journal = Tetrahedron Letters | volume = 31 | issue = 2 | pages = 205}} {{DEFAULTSORT:Pybop}}{{Organic-compound-stub}}2. ^{{Cite journal | title = Novel Condensation of D-LA into D-LSD via PyPOB [sic] | year = 2005 | last = Hardison | first = Casey William | journal = The Entheogen Review | volume = XIV | issue = 1 | pages = 94}} 8 : Hexafluorophosphates|Peptide coupling reagents|Benzotriazoles|Pyrrolidines|Biochemistry|Biochemistry methods|Reagents for biochemistry|Quaternary phosphonium compounds |
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