“Pyrimidodiazepine synthase”的意思、由来-开放百科全书

词条

Pyrimidodiazepine synthase

释义

References

{{enzyme
| Name = pyrimidodiazepine synthase
| EC_number = 1.5.4.1
| CAS_number = 93586-06-2
| IUBMB_EC_number = 1/5/4/1
| GO_code = 0004734
| image =
| width =
| caption =
}}

In enzymology, a pyrimidodiazepine synthase ({{EC number|1.5.4.1}}) is an enzyme that catalyzes the chemical reaction

a pyrimidodiazepine + glutathione disulfide + H₂O 6-pyruvoyltetrahydropterin + 2 glutathione

The 3 substrates of this enzyme are pyrimidodiazepine, glutathione disulfide, and H₂O, whereas its two products are 6-pyruvoyltetrahydropterin and glutathione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with a disulfide as acceptor. The systematic name of this enzyme class is pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing). Other names in common use include PDA synthase, pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening,, and cyclizing). This enzyme participates in glutathione metabolism.

References

{{cite journal | vauthors = Wiederrecht GJ, Brown GM | date = 1984 | title = Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins | journal = J. Biol. Chem. | volume = 259 | pages = 14121–7 | pmid = 6438092 | issue = 22 }}

2 : EC 1.5.4|Enzymes of unknown structure

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