| 词条 | Pyrithyldione |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 464377493 | IUPAC_name = 3,3-diethylpyridine-2,4(1H,3H)-dione | image = pyrithyldione.png | width = 120px | image2 = Pyrithyldione ball-and-stick.png | width2 = 120px | tradename = Benedorm, Didropyridine, Dihydroprylone, Persedon, Presidon, Pyridion, Pyridione, Pyrithyldion, Pyrithyldione, Tetridin, Tetridine | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 77-04-3 | ATC_prefix = N05 | ATC_suffix = CE03 | PubChem = 4994 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1722501 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4820 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 8AB20823CK | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07329 | C=9 | H=13 | N=1 | O=2 | molecular_weight = 167.205 g/mol | smiles = O=C1N/C=C\\C(=O)C1(CC)CC | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C9H13NO2/c1-3-9(4-2)7(11)5-6-10-8(9)12/h5-6H,3-4H2,1-2H3,(H,10,12) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = NZASCBIBXNPDMH-UHFFFAOYSA-N }}Pyrithyldione (Presidon, Persedon) is a psychoactive drug invented in 1949.[1] An improved method of manufacture was patented by Roche in 1959.[2] It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates.[3] Today, this substance is no longer used. Agranulocytosis was sometimes reported as adverse effect.[4][5] See also
References1. ^{{Cite journal | last1 = Becker | first1 = E. L. | last2 = Fabing | first2 = H. D. | last3 = Hawkins | first3 = J. R. | title = Presidon; A New Sedative-Hypnotic | journal = Christ Hospital Medical Bulletin | volume = 2 | issue = 4 | pages = 80–84 | year = 1949 | pmid = 18144514}} {{Hypnotics and sedatives}}{{GABAAR PAMs}}{{sedative-stub}}2. ^{{ cite patent | country = US | status = patent | number = 3019230 | invent1 = Hinderling, R. | invent2 = Lutz, A. H.| invent3 = Schnider, O. | assign1 = Hoffmann-La Roche | title = Method for the preparation of 2,4-dioxo-tetrahydropyridines | gdate = 1962-01-30}} 3. ^{{Cite journal | last1 = Pribilla | first1 = O. | doi = 10.1007/BF00577351 | title = Zur Toxikologie des Persedons | journal = Archiv für Toxikologie | volume = 16 | issue = 1| pages = 34–49 | year = 1956 }} 4. ^{{Cite journal | last1 = Ibáñez | first1 = L. | last2 = Ballarín | first2 = E. | last3 = Pérez | first3 = E. | last4 = Vidal | first4 = X. | last5 = Capellà | first5 = D. | last6 = Laporte | first6 = J. R. | title = Agranulocytosis Induced by Pyrithyldione, a Sedative Hypnotic Drug | journal = European Journal of Clinical Pharmacology | volume = 55 | issue = 10 | pages = 761–764 | year = 2000 | pmid = 10663456| doi = 10.1007/s002280050011}} 5. ^{{Cite journal | last1 = Covner | first1 = A. H. | last2 = Halpern | first2 = S. L. | doi = 10.1056/NEJM195001122420203 | title = Fatal Agranulocytosis Following Therapy with Presidon (3,3-Diethyl-2,4-Dioxotetrahydropyridine), a New Sedative Hypnotic Agent | journal = New England Journal of Medicine | volume = 242 | issue = 2 | pages = 49–52 | year = 1950 | pmid = 15399031 | pmc = }} 6 : Hypnotics|Lactams|Ketones|Piperidines|GABAA receptor positive allosteric modulators|Abandoned drugs |
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