“Pyruvate dehydrogenase (cytochrome)”的意思、由来-开放百科全书

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Pyruvate dehydrogenase (cytochrome)

释义

References

{{enzyme
| Name = pyruvate dehydrogenase (cytochrome)
| EC_number = 1.2.2.2
| CAS_number = 9079-84-9
| IUBMB_EC_number = 1/2/2/2
| GO_code = 0008985
| image =
| width =
| caption =
}}

In enzymology, a pyruvate dehydrogenase (cytochrome) ({{EC number|1.2.2.2}}) is an enzyme that catalyzes the chemical reaction

pyruvate + ferricytochrome b₁ + H₂O acetate + CO₂ + ferrocytochrome b₁

The 3 substrates of this enzyme are pyruvate, ferricytochrome b1, and H₂O, whereas its 3 products are acetate, CO₂, and ferrocytochrome b1.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is pyruvate:ferricytochrome-b1 oxidoreductase. Other names in common use include pyruvate dehydrogenase, pyruvic dehydrogenase, pyruvic (cytochrome b1) dehydrogenase, pyruvate:ubiquinone-8-oxidoreductase, and pyruvate oxidase (ambiguous). This enzyme participates in pyruvate metabolism. It has 2 cofactors: FAD, and Thiamin diphosphate.

References

{{cite journal |author1 = Williams FR |author2 =Hager LP | date = 1961 | title = A crystalline flavin pyruvate oxidase | journal = J. Biol. Chem. | volume = 236 | pages = PC36–PC37 }}
{{cite journal | vauthors = Koland JG, Gennis RB | date = 1982 | title = Identification of an active site cysteine residue in Escherichia coli pyruvate oxidase | journal = J. Biol. Chem. | volume = 257 | pages = 6023–7 | pmid = 7042705 | issue = 11 }}

4 : EC 1.2.2|Flavin enzymes|Thiamin diphosphate enzymes|Enzymes of unknown structure

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