| 释义 |
- References
- Further reading
- External links
{{enzyme
| Name = Pyruvate dehydrogenase (NADP+)
| EC_number = 1.2.1.51
| CAS_number = 93389-35-6
| IUBMB_EC_number = 1/2/1/51
| GO_code = 0050243
| image =
| width =
| caption =
}}Pyruvate dehydrogenase (NADP+) {{EC number|1.2.1.51}} is an enzyme that should not be confused with Pyruvate dehydrogenase (acetyltransferase) {{EC number|1.2.4.1}}.[1][2]It catalyzes the following reaction: Pyruvate + Coenzyme A + NADP+ ⇒ acetyl-CoA + NADPH + H+ + CO2 References 1. ^{{cite journal | vauthors = Inui H, Miyatake K, Nakano Y, Kitaoka S | title = Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis | journal = Journal of Biochemistry | volume = 96 | issue = 3 | pages = 931–4 | date = September 1984 | pmid = 6438078 | doi = 10.1093/oxfordjournals.jbchem.a134913 }}
2. ^{{cite journal | vauthors = Inui H, Ono K, Miyatake K, Nakano Y, Kitaoka S | title = Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis | journal = The Journal of Biological Chemistry | volume = 262 | issue = 19 | pages = 9130–5 | date = July 1987 | pmid = 3110154 }}
{{clear}} Further reading {{Refbegin|32em}}- {{cite journal | vauthors = Ctrnacta V, Ault JG, Stejskal F, Keithly JS | title = Localization of pyruvate:NADP+ oxidoreductase in sporozoites of Cryptosporidium parvum | journal = The Journal of Eukaryotic Microbiology | volume = 53 | issue = 4 | pages = 225–31 | year = 2006 | pmid = 16872290 | doi = 10.1111/j.1550-7408.2006.00099.x | ref = {{SfnRef|Ctrnacta 2006}} }}
- {{cite journal | vauthors = Inui H, Miyatake K, Nakano Y, Kitaoka S | title = The physiological role of oxygen-sensitive pyruvate dehydrogenase in mitochondrial fatty acid synthesis in Euglena gracilis | journal = Archives of Biochemistry and Biophysics | volume = 237 | issue = 2 | pages = 423–9 | date = March 1985 | pmid = 3919646 | doi = 10.1016/0003-9861(85)90295-4 | ref = {{SfnRef|Inui 1985}} }}
- {{cite journal | vauthors = Inui H, Miyatake K, Nakano Y, Kitaoka S | title = Pyruvate:NADP+ oxidoreductase from Euglena gracilis: the kinetic properties of the enzyme | journal = Archives of Biochemistry and Biophysics | volume = 274 | issue = 2 | pages = 434–42 | date = November 1989 | pmid = 2508561 | doi = 10.1016/0003-9861(89)90456-6 | ref = {{SfnRef|Inui 1989}} }}
- {{cite journal | vauthors = Inui H, Miyatake K, Nakano Y, Kitaoka S | title = Pyruvate:NADP+ oxidoreductase from Euglena gracilis: mechanism of O2-inactivation of the enzyme and its stability in the aerobe | journal = Archives of Biochemistry and Biophysics | volume = 280 | issue = 2 | pages = 292–8 | date = August 1990 | pmid = 2114824 | doi = 10.1016/0003-9861(90)90332-S | ref = {{SfnRef|Inui 1990}} }}
- {{cite journal | vauthors = Inui H, Yamaji R, Saidoh H, Miyatake K, Nakano Y, Kitaoka S | title = Pyruvate:NADP+ oxidoreductase from Euglena gracilis: limited proteolysis of the enzyme with trypsin | journal = Archives of Biochemistry and Biophysics | volume = 286 | issue = 1 | pages = 270–6 | date = April 1991 | pmid = 1910287 | doi = 10.1016/0003-9861(91)90040-P | ref = {{SfnRef|Inui 1991}} }}
- {{Cite journal |ref={{SfnRef|Lochmeyer 1990}} |author1=Lochmeyer, C.|author2=Fuchs, G. |year=1990 |title=NADP+-specific 2-oxoglutarate dehydrogenase in denitrifying Pseudomonas species |journal=Arch. Microbiol. |volume= 153 |pages=226–229 |doi=10.1007/BF00249072 |issue=3 }}
- {{cite journal | vauthors = Nakazawa M, Inui H, Yamaji R, Yamamoto T, Takenaka S, Ueda M, Nakano Y, Miyatake K | title = The origin of pyruvate: NADP+ oxidoreductase in mitochondria of Euglena gracilis | journal = FEBS Letters | volume = 479 | issue = 3 | pages = 155–6 | date = August 2000 | pmid = 11023353 | doi = 10.1016/S0014-5793(00)01882-2 | ref = {{SfnRef|Nakazawa 2000}} }}
- {{cite journal | vauthors = Nakazawa M, Takenaka S, Ueda M, Inui H, Nakano Y, Miyatake K | title = Pyruvate:NADP+ oxidoreductase is stabilized by its cofactor, thiamin pyrophosphate, in mitochondria of Euglena gracilis | journal = Archives of Biochemistry and Biophysics | volume = 411 | issue = 2 | pages = 183–8 | date = March 2003 | pmid = 12623066 | doi = 10.1016/S0003-9861(02)00749-X | ref = {{SfnRef|Nakazawa 2003}} }}
- {{cite journal | vauthors = Sawada K, Taki A, Yamakawa T, Seki M | title = Key role for transketolase activity in erythritol production by Trichosporonoides megachiliensis SN-G42 | journal = Journal of Bioscience and Bioengineering | volume = 108 | issue = 5 | pages = 385–90 | date = November 2009 | pmid = 19804861 | doi = 10.1016/j.jbiosc.2009.05.008 | ref = {{SfnRef|Sawada 2009}} }}
{{Refend}} External links {{Refbegin}}- EC 1.2.1.51 IUBMB Enzyme Nomenclature at chem.qmul.ac.uk
- EC 1.2.1.51 - pyruvate dehydrogenase (NADP+) at Brenda-enzymes.org
- ENZYME entry: EC 1.2.1.51 at Enzyme.expasy.org
{{Refend}}{{Aldehyde/Oxo oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}} 2 : Autoantigens|EC 1.2.1 |