| 词条 | Qrr RNA |
| 释义 |
| Name = Quorum regulatory RNA | image = RF00378.jpg | width = 270px | caption = | Symbol = Qrr | AltSymbols = Qrr1-5 | Rfam = RF00378 | RNA_type = sRNA | Tax_domain = Vibrio }}Qrr (Quorum regulatory RNA)[1] is a non-coding RNA that is thought to be involved in the regulation of quorum sensing in Vibrio species. It is believed that these RNAs, guided by a protein, Hfq, can mediate the destabilisation of the quorum-sensing master regulators LuxR/HapR/VanT mRNAs.[2][3] Qrr operates as part of a negative feedback loop which regulates the shift in cell state from that of low density populations to that in high density populations.[4] In Vibrio harveyi, Qrr binds and represses expression of the luxR mRNA transcript, a master regulator of quorum-sensing genes.[5] At higher population densities, increased autoinducer concentration leads to termination of qrr transcription hence derepression of luxR.[4] There are 5 different qrr genes (Qrr1-5) in V. harveyi; of these, qrr2, 3 and 4 are activated by LuxR.[6] References1. ^{{cite journal | last = Lenz | first = DH |author2=Mok KC |author3=Lilley BN |author4=Kulkarni RV |author5=Wingreen NS |author6=Bassler BL | year = 2004 | title = The Small RNA Chaperone Hfq and Multiple Small RNAs Control Quorum Sensing in Vibrio harveyi and Vibrio cholerae | journal = Cell | volume = 118 | pages = 69–82 | pmid = 15242645 | doi = 10.1016/j.cell.2004.06.009 | issue = 1}} 2. ^{{cite journal |vauthors=Svenningsen SL, Tu KC, Bassler BL |title=Gene dosage compensation calibrates four regulatory RNAs to control Vibrio cholerae quorum sensing |journal=EMBO J |volume=28 |issue=4 |pages=429–39 |year=2009 |pmid=19165149 |doi=10.1038/emboj.2008.300 |pmc=2632942}} 3. ^{{Cite journal| first1 = K. | first2 = C.| last1 = Tu| last4 = Bassler | first3 = S. | first4 = B.| title = A small-RNA-mediated negative feedback loop controls quorum-sensing dynamics in Vibrio harveyi| volume = 70| last3 = Svenningsen| journal = Molecular Microbiology| issue = 4| pages = 896–907| date=Nov 2008 | issn = 0950-382X| pmid = 18808382| pmc = 2680268| last2 = Waters| doi = 10.1111/j.1365-2958.2008.06452.x}} 4. ^1 {{cite journal |vauthors=Tu KC, Long T, Svenningsen SL, Wingreen NS, Bassler BL |title=Negative Feedback Loops Involving Small Regulatory RNAs Precisely Control the Vibrio harveyi Quorum-Sensing Response |journal=Mol Cell |volume=37 |issue=4 |pages=567–79 |year=2010 |pmid=20188674 |doi=10.1016/j.molcel.2010.01.022 |pmc=2844700}} 5. ^{{cite journal|last=Miyamoto|first=CM |author2=Smith, EE |author3=Swartzman, E |author4=Cao, JG |author5=Graham, AF |author6=Meighen, EA|title=Proximal and distal sites bind LuxR independently and activate expression of the Vibrio harveyi lux operon|journal=Molecular Microbiology|date=October 1994|volume=14|issue=2|pages=255–62|pmid=7830570|doi=10.1111/j.1365-2958.1994.tb01286.x}} 6. ^{{cite journal|last=Tu|first=KC |author2=Waters, CM |author3=Svenningsen, SL |author4=Bassler, BL|title=A small-RNA-mediated negative feedback loop controls quorum-sensing dynamics in Vibrio harveyi|journal=Molecular Microbiology|date=November 2008|volume=70|issue=4|pages=896–907|pmid=18808382|doi=10.1111/j.1365-2958.2008.06452.x|pmc=2680268}} Further reading
External links
1 : Non-coding RNA |
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