“Quinaldine”的意思、由来-开放百科全书

词条

Quinaldine

释义

Production
Uses
References
External links

{{chembox
| Verifiedfields = changed
| verifiedrevid = 433358304
| ImageFile = Quinaldine.png
| ImageSize =
| IUPACName = 2-Methylquinoline
| OtherNames = Quinaldine, α-methylquinoline, chinaldine, khinaldin
|Section1={{Chembox Identifiers
| CASNo = 91-63-4
| CASNo_Ref = {{cascite|correct|CAS}}
| EINECS = 202-085-1
| PubChem = 7060
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 194931
| SMILES = Cc1nc2ccccc2cc1
| InChI = 1/C10H9N/c1-8-6-7-9-4-2-3-5-10(9)11-8/h2-7H,1H3
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 13870160
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = SMUQFGGVLNAIOZ-UHFFFAOYSA-N
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI=1S/C10H9N/c1-8-6-7-9-4-2-3-5-10(9)11-8/h2-7H,1H3
|Section2={{Chembox Properties
| Formula = C₁₀H₉N
| MolarMass = 143.19 g/mol
| Appearance = colorless oil
| Density = 1.058 g/cm³
| MeltingPtC = -2
| BoilingPtC = 248
| Solubility = Insoluble
|Section7={{Chembox Hazards
| MainHazards = Harmful (Xn), Corrosive (C)
| NFPA-H = 2
| NFPA-F = 2
| NFPA-R = 0
| NFPA-S =
| RPhrases = {{R21/22}} {{R34}}
| SPhrases =
| FlashPtC = 79
| AutoignitionPtC =
}}Quinaldine or 2-methylquinoline is an organic compound with the formula CH₃C₉H₆N. It is one of the methyl derivative of a heterocyclic compound quinoline. It is bioactive and is used in the preparation of various dyes. It is a colorless oil but commercial samples can be colored.^[1]

Production

It is recovered from coal tar. It can be prepared from aniline and paraldehyde via Skraup synthesis or from aniline and crotonaldehyde via Doebner-von Miller variation of the Skraup reaction.^[1]

Uses

Quinaldine is used in anti-malaria drugs, in manufacturing dyes, food colorants (e.g., Quinoline Yellows, pinacyanol), pharmaceuticals. It is the precursor to the pH indicator Quinaldine Red.

Quinaldine sulfate is an anaesthetic used in fish transportation.^[2] In some Caribbean islands it is used to facilitate the collection of tropical fish from reefs.

Quinaldine has critical point at 787 K and 4.9 MPa and its refractive index is 1.8116.

References

1. ^¹{{Ullmann | author1 = Gerd Collin | author2 = Hartmut Höke | title = Quinoline and Isoquinoline | doi = 10.1002/14356007.a22_465}}
2. ^{{cite journal | author = Blasiola G. C. Jr. | year = 1977 | title = Quinaldine sulphate, a new anaesthetic formulation for tropical marine fishes | journal = Journal of Fish Biology | volume = 10 | issue = 2 | pages = 113–119(7) | pmid = | doi = 10.1111/j.1095-8649.1977.tb04048.x | url = http://www.blackwell-synergy.com/doi/abs/10.1111/j.1095-8649.1977.tb04048.x | accessdate = 2007-07-16 }}

External links

MSDS at Science Lab
Method of purifying quinaldine
{{cite EB1911 |wstitle=Quinoline |volume=22 |pages=758–760}}

1 : Quinolines

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