“(R)-4-hydroxyphenyllactate dehydrogenase”的意思、由来-开放百科全书

词条

(R)-4-hydroxyphenyllactate dehydrogenase

释义

References

{{enzyme
| Name = (R)-4-hydroxyphenyllactate dehydrogenase
| EC_number = 1.1.1.222
| CAS_number = 101754-02-3
| IUBMB_EC_number = 1/1/1/222
| GO_code = 0047029
| image =
| width =
| caption =
}}

In enzymology, a (R)-4-hydroxyphenyllactate dehydrogenase ({{EC number|1.1.1.222}}) is an enzyme that catalyzes the chemical reaction

(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (R)-3-(4-hydroxyphenyl)lactate, NAD⁺, and NADP⁺, whereas its 4 products are 3-(4-hydroxyphenyl)pyruvate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-3-(4-hydroxyphenyl)lactate:NAD(P)⁺ 2-oxidoreductase. Other names in common use include (R)-aromatic lactate dehydrogenase, and D-hydrogenase, D-aryllactate. This enzyme participates in tyrosine and phenylalanine catabolism.

References

{{cite journal |vauthors=Bode R, Lippoldt A, Birnbaum D | date = 1986 | title = Purification and properties of D-aromatic lactate dehydrogenase an enzyme involved in the catabolism of the aromatic amino acids of Candida maltosa | journal = Biochem. Physiol. Pflanzen | volume = 181 | pages = 189–198 }}
{{cite journal |vauthors=Leelayoova S, Marbury D, Rainey PM, Mackenzie NE, Hall JE |title=In vitro tryptophan catabolism by Leishmania donovani donovani promastigotes |journal=J. Protozool. |volume=39 |issue=2 |pages=350–8 |year=1992 |pmid=1578411 |doi=10.1111/j.1550-7408.1992.tb01329.x}}

4 : EC 1.1.1|NADPH-dependent enzymes|NADH-dependent enzymes|Enzymes of unknown structure

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