“(R)-6-hydroxynicotine oxidase”的意思、由来-开放百科全书

词条

(R)-6-hydroxynicotine oxidase

释义

Structural studies
References

{{enzyme
| Name = (R)-6-hydroxynicotine oxidase
| EC_number = 1.5.3.6
| CAS_number = 37233-46-8
| IUBMB_EC_number = 1/5/3/6
| GO_code = 0018530
| image =
| width =
| caption =
}}

In enzymology, a (R)-6-hydroxynicotine oxidase ({{EC number|1.5.3.6}}) is an enzyme that catalyzes the chemical reaction

(R)-6-hydroxynicotine + H₂O + O₂ 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H₂O₂

The 3 substrates of this enzyme are (R)-6-hydroxynicotine, H₂O, and O₂, whereas its two products are 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is (R)-6-hydroxynicotine:oxygen oxidoreductase. Other names in common use include D-6-hydroxynicotine oxidase, and 6-hydroxy-D-nicotine oxidase. It employs one cofactor, FAD.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2BVF}}, {{PDB link|2BVG}}, and {{PDB link|2BVH}}.

References

{{cite journal |vauthors=Bruhmuller M, Mohler H, Decker K | date = 1972 | title = Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Purification and properties of D-6-hydroxynicotine oxidase | journal = Eur. J. Biochem. | volume = 29 | pages = 143–51 | pmid = 4628374 | doi = 10.1111/j.1432-1033.1972.tb01968.x | issue = 1 }}
{{cite journal |vauthors=Decker K, Bleeg H | date = 1965 | title = Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans | journal = Biochim. Biophys. Acta | volume = 105 | pages = 313–24 | pmid = 5849820 | issue = 2 | doi=10.1016/s0926-6593(65)80155-2}}

3 : EC 1.5.3|Flavin enzymes|Enzymes of known structure

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