| 词条 | Rabbit syndrome |
| 释义 |
Rabbit syndrome is a rare[1] form of extrapyramidal side effect of antipsychotic drugs in which perioral tremors occur at a rate of approximately 5 Hz.[2] Rabbit syndrome is characterized by involuntary, fine, rhythmic motions of the mouth along a vertical plane, without involvement of the tongue.[3][4] It is usually seen after years of pharmacotherapy, and is more prominent with high potency drugs like haloperidol, fluphenazine, and pimozide. There is also a low incidence with thioridazine, clozapine, olanzapine, aripiprazole,[5] and low doses of risperidone. Rabbit syndrome can be treated with anticholinergic drugs. It generally disappears within a few days of treatment but may re-emerge after anticholinergic treatment is stopped. Another treatment strategy is to switch the patient to an atypical antipsychotic with high anti-cholinergic properties.[4] References1. ^{{cite journal |pmid=2870650 |year=1986 |author1=Yassa |first1=R |title=Prevalence of the rabbit syndrome |journal=American Journal of Psychiatry |volume=143 |issue=5 |pages=656–7 |last2=Lal |first2=S |doi=10.1176/ajp.143.5.656 }} {{disease-stub}}2. ^{{cite journal |pmid=15015902 |year=2004 |author1=Schwartz |first1=M |title=Antipsychotic-induced rabbit syndrome: Epidemiology, management and pathophysiology |journal=CNS Drugs |volume=18 |issue=4 |pages=213–20 |last2=Hocherman |first2=S |doi=10.2165/00023210-200418040-00002 }} 3. ^{{cite journal |pmid=5042912 |year=1972 |author1=Villeneuve |first1=A |title=The rabbit syndrome. A peculiar extrapyramidal reaction |journal=Canadian Psychiatric Association Journal |volume=17 |issue=2 |pages=Suppl 2:SS69– }} 4. ^1 {{cite journal |doi=10.1186/1745-0179-3-6 |pmid=17562001 |pmc=1914060 |title=Newer antipsychotics and the rabbit syndrome |journal=Clinical Practice and Epidemiology in Mental Health |volume=3 |pages=6 |year=2007 |last1=Catena Dell'Osso |first1=Mario |last2=Fagiolini |first2=Andrea |last3=Ducci |first3=Francesca |last4=Masalehdan |first4=Azadeh |last5=Ciapparelli |first5=Antonio |last6=Frank |first6=Ellen }} 5. ^{{cite journal |doi=10.1016/j.schres.2008.01.008 |pmid=18262773 |title=Aripiprazole-induced rabbit syndrome in a drug-naive schizophrenic patient |journal=Schizophrenia Research |volume=103 |issue=1–3 |pages=341–2 |year=2008 |last1=Gonidakis |first1=F |last2=Ploubidis |first2=D |last3=Papadimitriou |first3=G }} 4 : Neurological disorders|Rare diseases|Extrapyramidal and movement disorders|Syndromes |
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