| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene.[1] Function Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO (see MIM 165370), RAC (see RAC1; MIM 602048), and CDC42 (MIM 116952). GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.[supplied by OMIM][2] Interactions RACGAP1 has been shown to interact with Rnd2[3] and SLC26A8.[4] During cytokinesis, RACGAP1 has been shown to interact with KIF23 to form the centralspindlin complex.[5] This complex is essential for the formation of the central spindle. RACGAP1 also interacts with PRC1 to stabilize and maintain the central spindle as anaphase proceeds.[6] References 1. ^{{cite journal | vauthors = Touré A, Dorseuil O, Morin L, Timmons P, Jégou B, Reibel L, Gacon G | title = MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 11 | pages = 6019–23 | date = March 1998 | pmid = 9497316 | pmc = | doi = 10.1074/jbc.273.11.6019 }}
2. ^{{cite web | title = Entrez Gene: RACGAP1 Rac GTPase activating protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29127| accessdate = }}
3. ^{{cite journal | vauthors = Naud N, Touré A, Liu J, Pineau C, Morin L, Dorseuil O, Escalier D, Chardin P, Gacon G | title = Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells | journal = The Biochemical Journal | volume = 372 | issue = Pt 1 | pages = 105–12 | date = May 2003 | pmid = 12590651 | pmc = 1223378 | doi = 10.1042/BJ20021652 }}
4. ^{{cite journal | vauthors = Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G | title = Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling | journal = The Journal of Biological Chemistry | volume = 276 | issue = 23 | pages = 20309–15 | date = June 2001 | pmid = 11278976 | doi = 10.1074/jbc.M011740200 }}
5. ^{{cite journal | vauthors = Glotzer M | title = Cytokinesis: centralspindlin moonlights as a membrane anchor | journal = Current Biology | volume = 23 | issue = 4 | pages = R145–7 | date = February 2013 | pmid = 23428321 | doi = 10.1016/j.cub.2013.01.006 }}
6. ^{{cite journal | vauthors = Lee KY, Esmaeili B, Zealley B, Mishima M | title = Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle | journal = Nature Communications | volume = 6 | pages = 7290 | date = 2015 | pmid = 26088160 | doi = 10.1038/ncomms8290 | pmc=4557309}}
{{clear}} Further reading {{Refbegin|33em}}- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Gerwins P, Blank JL, Johnson GL | title = Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway | journal = The Journal of Biological Chemistry | volume = 272 | issue = 13 | pages = 8288–95 | date = March 1997 | pmid = 9079650 | doi = 10.1074/jbc.272.13.8288 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors = ((Nagata Ki)), Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A | title = The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 | journal = The EMBO Journal | volume = 17 | issue = 1 | pages = 149–58 | date = January 1998 | pmid = 9427749 | pmc = 1170366 | doi = 10.1093/emboj/17.1.149 }}
- {{cite journal | vauthors = Tapon N, Nagata K, Lamarche N, Hall A | title = A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1395–404 | date = March 1998 | pmid = 9482736 | pmc = 1170487 | doi = 10.1093/emboj/17.5.1395 }}
- {{cite journal | vauthors = Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A | title = PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia | journal = The EMBO Journal | volume = 17 | issue = 22 | pages = 6527–40 | date = November 1998 | pmid = 9822598 | pmc = 1171000 | doi = 10.1093/emboj/17.22.6527 }}
- {{cite journal | vauthors = Zuber J, Tchernitsa OI, Hinzmann B, Schmitz AC, Grips M, Hellriegel M, Sers C, Rosenthal A, Schäfer R | title = A genome-wide survey of RAS transformation targets | journal = Nature Genetics | volume = 24 | issue = 2 | pages = 144–52 | date = February 2000 | pmid = 10655059 | doi = 10.1038/72799 }}
- {{cite journal | vauthors = Das B, Shu X, Day GJ, Han J, Krishna UM, Falck JR, Broek D | title = Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding | journal = The Journal of Biological Chemistry | volume = 275 | issue = 20 | pages = 15074–81 | date = May 2000 | pmid = 10748082 | doi = 10.1074/jbc.M907269199 }}
- {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 7 | issue = 2 | pages = 143–50 | date = April 2000 | pmid = 10819331 | doi = 10.1093/dnares/7.2.143 }}
- {{cite journal | vauthors = Kawashima T, Hirose K, Satoh T, Kaneko A, Ikeda Y, Kaziro Y, Nosaka T, Kitamura T | title = MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells | journal = Blood | volume = 96 | issue = 6 | pages = 2116–24 | date = September 2000 | pmid = 10979956 | doi = }}
- {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
- {{cite journal | vauthors = Hirose K, Kawashima T, Iwamoto I, Nosaka T, Kitamura T | title = MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody | journal = The Journal of Biological Chemistry | volume = 276 | issue = 8 | pages = 5821–8 | date = February 2001 | pmid = 11085985 | doi = 10.1074/jbc.M007252200 }}
- {{cite journal | vauthors = Caloca MJ, Wang H, Delemos A, Wang S, Kazanietz MG | title = Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 18303–12 | date = May 2001 | pmid = 11278894 | doi = 10.1074/jbc.M011368200 }}
- {{cite journal | vauthors = Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G | title = Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling | journal = The Journal of Biological Chemistry | volume = 276 | issue = 23 | pages = 20309–15 | date = June 2001 | pmid = 11278976 | doi = 10.1074/jbc.M011740200 }}
- {{cite journal | vauthors = Mishima M, Kaitna S, Glotzer M | title = Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity | journal = Developmental Cell | volume = 2 | issue = 1 | pages = 41–54 | date = January 2002 | pmid = 11782313 | doi = 10.1016/S1534-5807(01)00110-1 }}
- {{cite journal | vauthors = Vikis HG, Li W, Guan KL | title = The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding | journal = Genes & Development | volume = 16 | issue = 7 | pages = 836–45 | date = April 2002 | pmid = 11937491 | pmc = 186329 | doi = 10.1101/gad.966402 }}
- {{cite journal | vauthors = Kitamura T, Kawashima T, Minoshima Y, Tonozuka Y, Hirose K, Nosaka T | title = Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation | journal = Cell Structure and Function | volume = 26 | issue = 6 | pages = 645–51 | date = December 2001 | pmid = 11942621 | doi = 10.1247/csf.26.645 }}
- {{cite journal | vauthors = Côté JF, Vuori K | title = Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity | journal = Journal of Cell Science | volume = 115 | issue = Pt 24 | pages = 4901–13 | date = December 2002 | pmid = 12432077 | doi = 10.1242/jcs.00219 }}
- {{cite journal | vauthors = Jantsch-Plunger V, Gönczy P, Romano A, Schnabel H, Hamill D, Schnabel R, Hyman AA, Glotzer M | title = CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis | journal = The Journal of Cell Biology | volume = 149 | issue = 7 | pages = 1391–404 | date = June 2000 | pmid = 10871280 | pmc = 2175131 | doi = 10.1083/jcb.149.7.1391 }}
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