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词条 Randomized experiment
释义

  1. Overview

  2. Online randomized controlled experiments

  3. History

  4. Statistical interpretation

  5. Empirical evidence that randomization makes a difference

  6. See also

  7. References

Overview

In the statistical theory of design of experiments, randomization involves randomly allocating the experimental units across the treatment groups. For example, if an experiment compares a new drug against a standard drug, then the patients should be allocated to either the new drug or to the standard drug control using randomization.

Randomized experimentation is not haphazard. Randomization reduces bias by equalising other factors that have not been explicitly accounted for in the experimental design (according to the law of large numbers). Randomization also produces ignorable designs, which are valuable in model-based statistical inference, especially Bayesian or likelihood-based. In the design of experiments, the simplest design for comparing treatments is the "completely randomized design". Some "restriction on randomization" can occur with blocking and experiments that have hard-to-change factors; additional restrictions on randomization can occur when a full randomization is infeasible or when it is desirable to reduce the variance of estimators of selected effects.

Randomization of treatment in clinical trials pose ethical problems. In some cases, randomization reduces the therapeutic options for both physician and patient, and so randomization requires clinical equipoise regarding the treatments.

Online randomized controlled experiments

Web sites can run randomized controlled experiments

[2] to create a feedback loop.[3] Key differences between offline experimentation and online experiments include:[3][4]
  • Logging: user interactions can be logged reliably.
  • Number of users: large sites, such as Amazon, Bing/Microsoft, and Google run experiments, each with over a million users.
  • Number of concurrent experiments: large sites run tens of overlapping, or concurrent, experiments.[5]
  • Robots, whether web crawlers from valid sources or malicious internet bots.
  • Ability to ramp-up experiments from low percentages to higher percentages.
  • Speed / performance has significant impact on key metrics.[3][6]
  • Ability to use the pre-experiment period as an A/A test to reduce variance.[7]

History

{{main|History of experiments}}

A controlled experiment appears to have been suggested in the Old Testament's Book of Daniel. King Nebuchadnezzar proposed that some Israelites eat "a daily amount of food and wine from the king's table." Daniel preferred a vegetarian diet, but the official was concerned that the king would "see you looking worse than the other young men your age? The king would then have my head because of you." Daniel then proposed the following controlled experiment: "Test your servants for ten days. Give us nothing but vegetables to eat and water to drink. Then compare our appearance with that of the young men who eat the royal food, and treat your servants in accordance with what you see". (Daniel 1, 12– 13).[8][9]

Randomized experiments were institutionalized in psychology and education in the late eighteen-hundreds, following the invention of randomized experiments by C. S. Peirce.[10][11][12][13]

Outside of psychology and education, randomized experiments were popularized by R.A. Fisher in his book Statistical Methods for Research Workers, which also introduced additional principles of experimental design.

Statistical interpretation

{{Expand section|date=September 2012}}

The Rubin Causal Model provides a common way to describe a randomized experiment. While the Rubin Causal Model provides a framework for defining the causal parameters (i.e., the effects of a randomized treatment on an outcome), the analysis of experiments can take a number of forms. Most commonly, randomized experiments are analyzed using ANOVA, student's t-test, regression analysis, or a similar statistical test.

Empirical evidence that randomization makes a difference

Empirically differences between randomized and non-randomized studies,[14] and between adequately and inadequately randomized trials have been difficult to detect.[15][16]

See also

  • A/B testing
  • Random assignment
  • Randomized block design
  • Randomized controlled trial

References

1. ^{{Cite journal | author = Schulz KF, Altman DG, Moher D; for the CONSORT Group |lastauthoramp=yes | title = CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials | journal = BMJ | volume = 340 | pages = c332 | year = 2010 | doi = 10.1136/bmj.c332 | url = http://www.bmj.com/cgi/content/full/340/mar23_1/c332 | pmid = 20332509 | pmc = 2844940 }}
2. ^{{cite book | last = Kohavi | first = Ron | author2 = Longbotham, Roger | title = Encyclopedia of Machine Learning and Data Mining | chapter= Online Controlled Experiments and A/B Tests | editor1-last= Sammut | editor1-first = Claude | editor2-last= Webb | editor2-first= Geoff | pages = to appear | publisher = Springer | year = 2015 | chapter-url = http://www.exp-platform.com/Documents/2015%20Online%20Controlled%20Experiments_EncyclopediaOfMLDM.pdf}}
3. ^1 2 {{cite journal | authors = Kohavi, Ron; Longbotham, Roger; Sommerfield, Dan; Henne, Randal M. | title = Controlled experiments on the web: survey and practical guide | journal = Data Mining and Knowledge Discovery | volume = 18 | issue = 1 | pages = 140–181 | year = 2009 | issn = 1384-5810 | doi = 10.1007/s10618-008-0114-1}}
4. ^{{cite conference | url= http://www.exp-platform.com/Pages/PuzzingOutcomesExplained.aspx | title=Trustworthy Online Controlled Experiments: Five Puzzling Outcomes Explained | last = Kohavi | first = Ron |author2=Deng, Alex |author3=Frasca, Brian |author4=Longbotham, Roger |author5=Walker, Toby |author6= Xu Ya | booktitle = Proceedings of the 18th ACM SIGKDD Conference on Knowledge Discovery and Data Mining | year = 2012}}
5. ^{{cite conference | last = Kohavi | first = Ron |author2=Deng Alex |author3=Frasca Brian |author4=Walker Toby |author5=Xu Ya |author6= Nils Pohlmann | title = Online Controlled Experiments at Large Scale | journal = Proceedings of the 19th ACM SIGKDD Conference on Knowledge Discovery and Data Mining | volume = 19 | pages = 1168–1176 | publisher = ACM | location = Chicago, Illinois, USA | year = 2013 | doi = 10.1145/2487575.2488217}}
6. ^{{cite conference | last = Kohavi | first = Ron | author2=Deng Alex |author3=Longbotham Roger |author4=Xu Ya | url = http://www.exp-platform.com/Pages/SevenRulesofThumbforWebSiteExperimenters.aspx | title = Seven Rules of Thumb for Web Site Experimenters | journal = Proceedings of the 20th ACM SIGKDD Conference on Knowledge Discovery and Data Mining | volume = 20 | pages = 1857–1866 | publisher = ACM | location = New York, New York, USA | year = 2014 | doi = 10.1145/2623330.2623341}}
7. ^{{cite conference | url= http://www.exp-platform.com/Pages/CUPED.aspx | title=Improving the Sensitivity of Online Controlled Experiments by Utilizing Pre-Experiment Data | last = Deng | first = Alex |author2=Xu, Ya |author3=Kohavi, Ron |author4=Walker, Toby | booktitle = WSDM 2013: Sixth ACM International Conference on Web Search and Data Mining | year = 2013}}
8. ^{{cite journal | last = Neuhauser | first = D |author2=Diaz, M | title = Daniel: using the Bible to teach quality improvement methods | journal = Quality and Safety in Health Care 2004 | volume = 13 | issue = 2 | pages = 153–155 | year = 2004 | doi = 10.1136/qshc.2003.009480 | pmid=15069225 | pmc=1743807}}
9. ^{{cite book | last = Angrist | first = Joshua | author2 = Pischke Jörn-Steffen | title = Mastering 'Metrics: The Path from Cause to Effect | publisher = Princeton University Press | year = 2014 | page = 31}}
10. ^{{cite journal| author=Charles Sanders Peirce and Joseph Jastrow| year=1885|title=On Small Differences in Sensation| journal=Memoirs of the National Academy of Sciences|volume=3|pages=73–83|url=http://psychclassics.yorku.ca/Peirce/small-diffs.htm}} http://psychclassics.yorku.ca/Peirce/small-diffs.htm
11. ^{{cite journal| doi=10.1086/354775| first=Ian |last=Hacking| authorlink=Ian Hacking | title=Telepathy: Origins of Randomization in Experimental Design|journal=Isis| issue=3| volume=79| date=September 1988 |pages=427–451| mr = 1013489| jstor=234674}}
12. ^{{cite journal| doi=10.1086/444032|author=Stephen M. Stigler|title=A Historical View of Statistical Concepts in Psychology and Educational Research| journal=American Journal of Education| volume=101| issue=1| date=November 1992|pages=60–70}}
13. ^{{cite journal|doi=10.1086/383850|author=Trudy Dehue|title=Deception, Efficiency, and Random Groups: Psychology and the Gradual Origination of the Random Group Design|journal=Isis| volume=88| issue=4| date=December 1997| pages=653–673|pmid=9519574}}
14. ^{{cite journal| doi=10.1002/14651858.MR000034.pub2|vauthors=Anglemyer A, Horvath HT, Bero L | title=Healthcare outcomes assessed with observational study designs compared with those assessed in randomized trials| journal=Cochrane Database Syst Rev|date=April 2014| pmid=24782322| volume=4|issue=4 | pages=MR000034}}
15. ^{{cite journal| doi=10.1002/14651858.MR000012.pub3| vauthors=Odgaard-Jensen J, Vist G, etal |title=Randomisation to protect against selection bias in healthcare trials.| journal=Cochrane Database Syst Rev| date=April 2011|pmid=21491415|pages=MR000012| issue=4}}
16. ^{{cite journal| doi=10.1186/1745-6215-15-480|vauthors=Howick J, Mebius A |title=In search of justification for the unpredictability paradox| journal=Trials| year=2014| volume=15| pmid=25490908| pages=480| pmc=4295227}}
  • {{cite book

|author1=Caliński, Tadeusz |author2=Kageyama, Sanpei
|lastauthoramp=yes |title=Block designs: A Randomization approach, Volume I: Analysis
|series=Lecture Notes in Statistics
|volume=150
|publisher=Springer-Verlag
|location=New York
|year=2000
|isbn=978-0-387-98578-7
}}
  • {{cite book

|author1=Caliński, Tadeusz |author2=Kageyama, Sanpei
|lastauthoramp=yes |title=Block designs: A Randomization approach, Volume II: Design
|series=Lecture Notes in Statistics
|volume=170
|publisher=Springer-Verlag
|location=New York
|year=2003
|isbn=978-0-387-95470-7
}}
  • {{cite journal|doi=10.1086/354775|first=Ian |last=Hacking| authorlink=Ian Hacking | title=Telepathy: Origins of Randomization in Experimental Design|journal=Isis|issue=3|volume=79|date=September 1988 |pages=427–451| mr = 1013489| jstor=234674}}
  • {{cite book| last1=Hinkelmann| first1=Klaus| last2=Kempthorne| first2=Oscar| year=2008| title=Design and Analysis of Experiments, Volume I: Introduction to Experimental Design| url=https://books.google.com/?id=T3wWj2kVYZgC&printsec=frontcover| edition=Second| publisher= Wiley | isbn=978-0-471-72756-9 |mr=2363107 |authorlink2=Oscar Kempthorne}}
  • {{cite book| last=Kempthorne|first=Oscar |chapter=Intervention experiments, randomization and inference|title=Current Issues in Statistical Inference—Essays in Honor of D. Basu | editor=Malay Ghosh and Pramod K. Pathak | pages=13–31 | publisher=Institute for Mathematical Statistics |location=Hayward, CA | chapter-url=http://projecteuclid.org/euclid.lnms/1215458836 | doi=10.1214/lnms/1215458836 | mr=1194407|authorlink=Oscar Kempthorne|series=Institute of Mathematical Statistics Lecture Notes - Monograph Series |year=1992 |isbn=978-0-940600-24-9 }}
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2 : Design of experiments|Experiments
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