“RAP1A”的意思、由来-开放百科全书

The product of this gene belongs to the family of Ras-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.^[2]

1. ^{{cite journal | vauthors = Kawata M, Matsui Y, Kondo J, Hishida T, Teranishi Y, Takai Y | title = A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization | journal = The Journal of Biological Chemistry | volume = 263 | issue = 35 | pages = 18965–71 | date = Dec 1988 | pmid = 3143720 | pmc = | doi = }}
2. ^{{cite web | title = Entrez Gene: RAP1A RAP1A, member of RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5906| accessdate = }}
3. ^{{cite journal | vauthors = Han L, Colicelli J | title = A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1 | journal = Molecular and Cellular Biology | volume = 15 | issue = 3 | pages = 1318–23 | date = Mar 1995 | pmid = 7862125 | pmc = 230355 | doi = 10.1128/mcb.15.3.1318}}
4. ^{{cite journal | vauthors = Nassar N, Horn G, Herrmann C, Scherer A, McCormick F, Wittinghofer A | title = The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue | journal = Nature | volume = 375 | issue = 6532 | pages = 554–60 | date = Jun 1995 | pmid = 7791872 | doi = 10.1038/375554a0 }}
5. ^{{cite journal | vauthors = Hu CD, Kariya K, Okada T, Qi X, Song C, Kataoka T | title = Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation | journal = The Journal of Biological Chemistry | volume = 274 | issue = 1 | pages = 48–51 | date = Jan 1999 | pmid = 9867809 | doi = 10.1074/jbc.274.1.48}}
6. ^{{cite journal | vauthors = Okada T, Hu CD, Jin TG, Kariya K, Yamawaki-Kataoka Y, Kataoka T | title = The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases | journal = Molecular and Cellular Biology | volume = 19 | issue = 9 | pages = 6057–64 | date = Sep 1999 | pmid = 10454553 | pmc = 84512 | doi = 10.1128/mcb.19.9.6057}}
7. ^{{cite journal | vauthors = Nancy V, Callebaut I, El Marjou A, de Gunzburg J | title = The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 17 | pages = 15076–84 | date = Apr 2002 | pmid = 11786539 | doi = 10.1074/jbc.M109983200 }}
8. ^{{cite journal | vauthors = Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC | title = The complex of Arl2-GTP and PDE delta: from structure to function | journal = The EMBO Journal | volume = 21 | issue = 9 | pages = 2095–106 | date = May 2002 | pmid = 11980706 | pmc = 125981 | doi = 10.1093/emboj/21.9.2095 }}
9. ^¹{{cite journal | vauthors = Boettner B, Govek EE, Cross J, Van Aelst L | title = The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 16 | pages = 9064–9 | date = Aug 2000 | pmid = 10922060 | pmc = 16822 | doi = 10.1073/pnas.97.16.9064}}
10. ^{{cite journal | vauthors = Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J | title = Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 13 | pages = 8737–45 | date = Mar 1999 | pmid = 10085114 | doi = 10.1074/jbc.274.13.8737}}
11. ^{{cite journal | vauthors = Rebhun JF, Castro AF, Quilliam LA | title = Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction | journal = The Journal of Biological Chemistry | volume = 275 | issue = 45 | pages = 34901–8 | date = Nov 2000 | pmid = 10934204 | doi = 10.1074/jbc.M005327200 }}
12. ^{{cite journal | vauthors = Castro AF, Rebhun JF, Clark GJ, Quilliam LA | title = Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner | journal = The Journal of Biological Chemistry | volume = 278 | issue = 35 | pages = 32493–6 | date = Aug 2003 | pmid = 12842888 | doi = 10.1074/jbc.C300226200 }}
13. ^{{cite journal | vauthors = Yamamoto Y, Jones KA, Mak BC, Muehlenbachs A, Yeung RS | title = Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin | journal = Archives of Biochemistry and Biophysics | volume = 404 | issue = 2 | pages = 210–7 | date = Aug 2002 | pmid = 12147258 | doi = 10.1016/s0003-9861(02)00300-4}}

Function

Interactions

References