“(R)-dehydropantoate dehydrogenase”的意思、由来-开放百科全书

词条

(R)-dehydropantoate dehydrogenase

释义

References

{{enzyme
| Name = (R)-dehydropantoate dehydrogenase
| EC_number = 1.2.1.33
| CAS_number = 37250-96-7
| IUBMB_EC_number = 1/2/1/33
| GO_code = 0047509
| image =
| width =
| caption =
}}

In enzymology, a (R)-dehydropantoate dehydrogenase ({{EC number|1.2.1.33}}) is an enzyme that catalyzes the chemical reaction

(R)-4-dehydropantoate + NAD⁺ + H₂O (R)-3,3-dimethylmalate + NADH + 2 H⁺

The 3 substrates of this enzyme are (R)-4-dehydropantoate, NAD⁺, and H₂O, whereas its 3 products are (R)-3,3-dimethylmalate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-4-dehydropantoate:NAD+ 4-oxidoreductase. Other names in common use include D-aldopantoate dehydrogenase, D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine, and nucleotide (DPN+) oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.

References

{{cite journal |vauthors=Magee PT, Snell EE | date = 1966 | title = The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to alpha-ketoisovalerate | journal = Biochemistry | volume = 5 | pages = 409–16 | pmid = 4287371 | doi = 10.1021/bi00866a004 | issue = 2 }}

3 : EC 1.2.1|NADH-dependent enzymes|Enzymes of unknown structure

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