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词条 Renal tissue kallikrein
释义

  1. See also

  2. References

  3. External links

{{Infobox enzyme
| Name = Tissue kallikrein
| EC_number = 3.4.21.35
| CAS_number = 389069-73-2
| IUBMB_EC_number = 3/4/21/35
| GO_code =
| image =
| width =
| caption =
}}Tissue kallikrein ({{EC number|3.4.21.35}}, glandular kallikrein, pancreatic kallikrein, submandibular kallikrein, submaxillary kallikrein, kidney kallikrein, urinary kallikrein, kallikrein, salivary kallikrein, kininogenin, kininogenase, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, depot-padutin, urokallikrein, dilminal D, onokrein P) is an enzyme.[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] This enzyme catalyses the following chemical reaction

Preferential cleavage of Arg- bonds in small molecule substrates. It acts highly selectively to release kallidin (lysyl-bradykinin) from kininogen

This enzyme is formed from tissue prokallikrein by activation with trypsin.

See also

  • Kallikrein
{{clear}}

References

1. ^{{cite journal | vauthors = Fiedler F, Fink E, Tschesche H, Fritz H | title = Porcine glandular kallikreins | journal = Methods in Enzymology | volume = 80 Pt C | pages = 493–532 | date = 1981 | pmid = 7043199 | doi = 10.1016/s0076-6879(81)80042-0 }}
2. ^{{cite journal | vauthors = Anundi H, Ronne H, Peterson PA, Rask L | title = Partial amino-acid sequence of the epidermal growth-factor-binding protein | journal = European Journal of Biochemistry | volume = 129 | issue = 2 | pages = 365–71 | date = December 1982 | pmid = 6295764 | doi = 10.1111/j.1432-1033.1982.tb07059.x }}
3. ^{{cite journal | vauthors = Pesquero JL, Boschcov P, Oliveira MC, Paiva AC | title = Effect of substrate size on tonin activity | journal = Biochemical and Biophysical Research Communications | volume = 108 | issue = 4 | pages = 1441–6 | date = October 1982 | pmid = 6295383 | doi = 10.1016/s0006-291x(82)80068-5 }}
4. ^{{cite journal | vauthors = Gutkowska J, Corvol P, Figueiredo AF, Inagami T, Bouhnik J, Genest J | title = Kinetic studies of rat renin and tonin on purified rat angiotensinogen | journal = Canadian Journal of Biochemistry and Cell Biology | volume = 62 | issue = 2-3 | pages = 137–42 | date = 1984 | pmid = 6097352 }}
5. ^{{cite journal | vauthors = Kato H, Enjyoji K, Miyata T, Hayashi I, Oh-ishi S, Iwanaga S | title = Demonstration of arginyl-bradykinin moiety in rat HMW kininogen: direct evidence for liberation of bradykinin by rat glandular kallikreins | journal = Biochemical and Biophysical Research Communications | volume = 127 | issue = 1 | pages = 289–95 | date = February 1985 | pmid = 3844939 | doi = 10.1016/s0006-291x(85)80157-1 }}
6. ^{{cite journal | vauthors = Akiyama K, Nakamura T, Iwanaga S, Hara M | title = The chymotrypsin-like activity of human prostate-specific antigen, gamma-seminoprotein | journal = FEBS Letters | volume = 225 | issue = 1-2 | pages = 168–72 | date = December 1987 | pmid = 3691800 | doi = 10.1016/0014-5793(87)81151-1 }}
7. ^{{cite journal | vauthors = Evans BA, Drinkwater CC, Richards RI | title = Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus | journal = The Journal of Biological Chemistry | volume = 262 | issue = 17 | pages = 8027–34 | date = June 1987 | pmid = 3036794 }}
8. ^{{cite journal | vauthors = Fiedler F | title = Effects of secondary interactions on the kinetics of peptide and peptide ester hydrolysis by tissue kallikrein and trypsin | journal = European Journal of Biochemistry | volume = 163 | issue = 2 | pages = 303–12 | date = March 1987 | pmid = 3643848 | doi = 10.1111/j.1432-1033.1987.tb10801.x }}
9. ^{{cite journal | vauthors = Fujinaga M, James MN | title = Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution | journal = Journal of Molecular Biology | volume = 195 | issue = 2 | pages = 373–96 | date = May 1987 | pmid = 2821276 | doi = 10.1016/0022-2836(87)90658-9 }}
10. ^{{cite journal | vauthors = Kato H, Nakanishi E, Enjyoji K, Hayashi I, Oh-ishi S, Iwanaga S | title = Characterization of serine proteinases isolated from rat submaxillary gland: with special reference to the degradation of rat kininogens by these enzymes | journal = Journal of Biochemistry | volume = 102 | issue = 6 | pages = 1389–404 | date = December 1987 | pmid = 3482210 }}
11. ^{{cite journal | vauthors = Bailey GS | title = Rat pancreas kallikrein | journal = Methods in Enzymology | volume = 163 | pages = 115–28 | date = 1989 | pmid = 3237072 | doi = 10.1016/0076-6879(88)63013-8 }}
12. ^{{cite journal | vauthors = Blaber M, Isackson PJ, Marsters JC, Burnier JP, Bradshaw RA | title = Substrate specificities of growth factor associated kallikreins of the mouse submandibular gland | journal = Biochemistry | volume = 28 | issue = 19 | pages = 7813–9 | date = September 1989 | pmid = 2611215 | doi = 10.1021/bi00445a043 }}
13. ^{{cite journal | vauthors = Chao J, Chao L | title = Rat urinary kallikrein | journal = Methods in Enzymology | volume = 163 | pages = 128–43 | date = 1988 | pmid = 3070295 | doi = 10.1016/0076-6879(88)63014-x }}
14. ^{{cite journal | vauthors = Geiger R, Miska W | title = Human tissue kallikrein | journal = Methods in Enzymology | volume = 163 | pages = 102–15 | date = 1988 | pmid = 3237071 | doi = 10.1016/0076-6879(88)63012-6 }}
15. ^{{cite journal | vauthors = Bertrand R, Derancourt J, Kassab R | title = Selective cleavage at lysine of the 50 kDa-20 kDa connector loop segment of skeletal myosin S-1 by endoproteinase Arg-C | journal = FEBS Letters | volume = 246 | issue = 1-2 | pages = 171–6 | date = March 1989 | pmid = 2523317 | doi = 10.1016/0014-5793(89)80277-7 }}
16. ^{{cite journal | vauthors = Wines DR, Brady JM, Pritchett DB, Roberts JL, MacDonald RJ | title = Organization and expression of the rat kallikrein gene family | journal = The Journal of Biological Chemistry | volume = 264 | issue = 13 | pages = 7653–62 | date = May 1989 | pmid = 2708383 }}
17. ^{{cite journal | vauthors = Elmoujahed A, Gutman N, Brillard M, Gauthier F | title = Substrate specificity of two kallikrein family gene products isolated from the rat submaxillary gland | journal = FEBS Letters | volume = 265 | issue = 1-2 | pages = 137–40 | date = June 1990 | pmid = 2194829 | doi = 10.1016/0014-5793(90)80903-v }}
18. ^{{cite journal | vauthors = Xiong W, Chen LM, Chao J | title = Purification and characterization of a kallikrein-like T-kininogenase | journal = The Journal of Biological Chemistry | volume = 265 | issue = 5 | pages = 2822–7 | date = February 1990 | pmid = 2303430 }}

External links

  • {{MeshName|Tissue+kallikrein}}
{{Serine endopeptidases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}

1 : EC 3.4.21

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