| 释义 |
- Interactions
- See also
- References
- Further reading
{{Infobox gene}}Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene.[1][2] Interactions Retinoic acid receptor gamma has been shown to interact with NCOR1.[3] See also References 1. ^{{cite web | title = Entrez Gene: RARG retinoic acid receptor, gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5916| accessdate = }}
2. ^{{cite journal | vauthors = Lehmann JM, Hoffmann B, Pfahl M | title = Genomic organization of the retinoic acid receptor gamma gene | journal = Nucleic Acids Research | volume = 19 | issue = 3 | pages = 573–8 | date = Feb 1991 | pmid = 1849262 | pmc = 333650 | doi = 10.1093/nar/19.3.573 }}
3. ^{{cite journal | vauthors = Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M | title = Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein | journal = The Journal of Biological Chemistry | volume = 274 | issue = 22 | pages = 15901–7 | date = May 1999 | pmid = 10336495 | doi = 10.1074/jbc.274.22.15901 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S | title = Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently | journal = Cell | volume = 68 | issue = 2 | pages = 377–95 | date = Jan 1992 | pmid = 1310259 | doi = 10.1016/0092-8674(92)90478-U }}
- {{cite journal | vauthors = Vollberg TM, Nervi C, George MD, Fujimoto W, Krust A, Jetten AM | title = Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation | journal = Molecular Endocrinology | volume = 6 | issue = 5 | pages = 667–76 | date = May 1992 | pmid = 1318502 | doi = 10.1210/me.6.5.667 }}
- {{cite journal | vauthors = Lehmann JM, Zhang XK, Pfahl M | title = RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites | journal = Molecular and Cellular Biology | volume = 12 | issue = 7 | pages = 2976–85 | date = Jul 1992 | pmid = 1320193 | pmc = 364511 | doi = 10.1128/mcb.12.7.2976}}
- {{cite journal | vauthors = Mattei MG, Rivière M, Krust A, Ingvarsson S, Vennström B, Islam MQ, Levan G, Kautner P, Zelent A, Chambon P | title = Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes | journal = Genomics | volume = 10 | issue = 4 | pages = 1061–9 | date = Aug 1991 | pmid = 1655630 | doi = 10.1016/0888-7543(91)90199-O }}
- {{cite journal | vauthors = Kastner P, Krust A, Mendelsohn C, Garnier JM, Zelent A, Leroy P, Staub A, Chambon P | title = Murine isoforms of retinoic acid receptor gamma with specific patterns of expression | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 7 | pages = 2700–4 | date = Apr 1990 | pmid = 2157210 | pmc = 53758 | doi = 10.1073/pnas.87.7.2700 }}
- {{cite journal | vauthors = Giguère V, Shago M, Zirngibl R, Tate P, Rossant J, Varmuza S | title = Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo | journal = Molecular and Cellular Biology | volume = 10 | issue = 5 | pages = 2335–40 | date = May 1990 | pmid = 2157970 | pmc = 360581 | doi = 10.1128/mcb.10.5.2335}}
- {{cite journal | vauthors = Ishikawa T, Umesono K, Mangelsdorf DJ, Aburatani H, Stanger BZ, Shibasaki Y, Imawari M, Evans RM, Takaku F | title = A functional retinoic acid receptor encoded by the gene on human chromosome 12 | journal = Molecular Endocrinology | volume = 4 | issue = 6 | pages = 837–44 | date = Jun 1990 | pmid = 2172793 | doi = 10.1210/mend-4-6-837 }}
- {{cite journal | vauthors = Krust A, Kastner P, Petkovich M, Zelent A, Chambon P | title = A third human retinoic acid receptor, hRAR-gamma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 14 | pages = 5310–4 | date = Jul 1989 | pmid = 2546152 | pmc = 297611 | doi = 10.1073/pnas.86.14.5310 }}
- {{cite journal | vauthors = Renaud JP, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D | title = Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid | journal = Nature | volume = 378 | issue = 6558 | pages = 681–9 | date = Dec 1995 | pmid = 7501014 | doi = 10.1038/378681a0 }}
- {{cite journal | vauthors = Zhou L, Pang J, Munroe DG, Lau C | title = A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7 | journal = Nucleic Acids Research | volume = 21 | issue = 10 | pages = 2520 | date = May 1993 | pmid = 7685085 | pmc = 309563 | doi = 10.1093/nar/21.10.2520 }}
- {{cite journal | vauthors = Zitnik RJ, Kotloff RM, Latifpour J, Zheng T, Whiting NL, Schwalb J, Elias JA | title = Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts | journal = Journal of Immunology | volume = 152 | issue = 3 | pages = 1419–27 | date = Feb 1994 | pmid = 8301142 | doi = }}
- {{cite journal | vauthors = Botling J, Castro DS, Oberg F, Nilsson K, Perlmann T | title = Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation | journal = The Journal of Biological Chemistry | volume = 272 | issue = 14 | pages = 9443–9 | date = Apr 1997 | pmid = 9083083 | doi = 10.1074/jbc.272.14.9443 }}
- {{cite journal | vauthors = Lømo J, Smeland EB, Ulven S, Natarajan V, Blomhoff R, Gandhi U, Dawson MI, Blomhoff HK | title = RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes | journal = Journal of Cellular Physiology | volume = 175 | issue = 1 | pages = 68–77 | date = Apr 1998 | pmid = 9491782 | doi = 10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A }}
- {{cite journal | vauthors = Klaholz BP, Renaud JP, Mitschler A, Zusi C, Chambon P, Gronemeyer H, Moras D | title = Conformational adaptation of agonists to the human nuclear receptor RAR gamma | journal = Nature Structural Biology | volume = 5 | issue = 3 | pages = 199–202 | date = Mar 1998 | pmid = 9501913 | doi = 10.1038/nsb0398-199 }}
- {{cite journal | vauthors = Zhang ZP, Gambone CJ, Gabriel JL, Wolfgang CL, Soprano KJ, Soprano DR | title = Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma | journal = The Journal of Biological Chemistry | volume = 273 | issue = 51 | pages = 34016–21 | date = Dec 1998 | pmid = 9852056 | doi = 10.1074/jbc.273.51.34016 }}
- {{cite journal | vauthors = Yang C, Zhou D, Chen S | title = Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor | journal = Cancer Research | volume = 58 | issue = 24 | pages = 5695–700 | date = Dec 1998 | pmid = 9865725 | doi = }}
- {{cite journal | vauthors = Nagpal S, Ghosn C, DiSepio D, Molina Y, Sutter M, Klein ES, Chandraratna RA | title = Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor | journal = The Journal of Biological Chemistry | volume = 274 | issue = 32 | pages = 22563–8 | date = Aug 1999 | pmid = 10428834 | doi = 10.1074/jbc.274.32.22563 }}
- {{cite journal | vauthors = Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D | title = Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid | journal = The EMBO Journal | volume = 19 | issue = 11 | pages = 2592–601 | date = Jun 2000 | pmid = 10835357 | pmc = 212755 | doi = 10.1093/emboj/19.11.2592 }}
- {{cite journal | vauthors = Boudjelal M, Voorhees JJ, Fisher GJ | title = Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells | journal = Experimental Cell Research | volume = 274 | issue = 1 | pages = 130–7 | date = Mar 2002 | pmid = 11855864 | doi = 10.1006/excr.2001.5450 }}
{{refend}}{{gene-12-stub}}{{PDB Gallery|geneid=5916}}{{Transcription factors|g2}}{{Retinoid receptor modulators}} 2 : Intracellular receptors|Transcription factors |