| 释义 |
- References
- Further reading
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{{Infobox rfam
| Name = RNAIII
| image = RF00503.jpg
| width =
| caption = Predicted secondary structure and sequence conservation of RNAIII
| Symbol = RNAIII
| AltSymbols =
| Rfam = RF00503
| miRBase =
| miRBase_family =
| RNA_type = Gene
| Tax_domain = Bacteria
| GO =
| SO = {{SO|0005836}}
| CAS_number =
| EntrezGene =
| HGNCid =
| OMIM =
| PDB =
| RefSeq =
| Chromosome =
| Arm =
| Band =
| LocusSupplementaryData =
}}RNAIII is a small RNA which is known to regulate the expression of many Staphylococcus aureus genes encoding exoproteins and cell wall associated proteins.[1] In S. aureus, RNAIII acts as the effector of the agr quorum sensing system and is transcribed from the P3 operon. The RNAIII transcript also contains the 26 amino acid delta-haemolysin gene (hld).[2] RNAIII regulates the expression of the transcription factor rot by blocking its translation. It has been suggested that RNAIII binds to the rot mRNA in an antisense fashion occluding the Shine-Dalgarno sequence.[3][4]References1. ^{{cite journal |vauthors=Waters LS, Storz G |title=Regulatory RNAs in Bacteria |journal=Cell |volume=136 |issue=4 |pages=615–28 |date=February 2009 |pmid=19239884 |doi=10.1016/j.cell.2009.01.043 |url= |pmc=3132550}}
2. ^{{cite journal | last = Benito | first = Y |author2=Kolb FA |author3=Romby P |author4=Lina G |author5=Etienne J |author6=Vandenesch F | year = 2000 | title = Probing the structure of RNAIII, the Staphylococcus aureus agr regulatory RNA, and identification of the RNA domain involved in repression of protein A expression | journal = RNA | volume = 6 | pages = 668–679 | pmid = 10836788 | doi = 10.1017/S1355838200992550 | issue = 5 | pmc = 1369947}}
3. ^{{cite journal |vauthors=Geisinger E, Adhikari RP, Jin R, Ross HF, Novick RP | title = Inhibition of rot translation by RNAIII, a key feature of agr function | journal = Mol. Microbiol. | volume = 61 | issue = 4 | pages = 1038–48 | year = 2006 | pmid = 16879652 | doi = 10.1111/j.1365-2958.2006.05292.x }}
4. ^{{cite journal |vauthors=Boisset S, Geissmann T, Huntzinger E, etal |title=Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism |journal=Genes Dev. |volume=21 |issue=11 |pages=1353–66 |date=June 2007 |pmid=17545468 |pmc=1877748 |doi=10.1101/gad.423507 |url=}}
Further reading- {{cite journal |vauthors=Chevalier C, Boisset S, Romilly C, etal |title=Staphylococcus aureus RNAIII Binds to Two Distant Regions of coa mRNA to Arrest Translation and Promote mRNA Degradation |journal=PLoS Pathog. |volume=6 |issue=3 |pages=e1000809 |date=March 2010 |pmid=20300607 |pmc=2837412 |doi=10.1371/journal.ppat.1000809 |url= |editor1-last=Cheung |editor1-first=Ambrose}}
- {{cite journal |vauthors=Coelho LR, Souza RR, Ferreira FA, Guimarães MA, Ferreira-Carvalho BT, Figueiredo AM |title=agr RNAIII divergently regulates glucose-induced biofilm formation in clinical isolates of Staphylococcus aureus |journal=Microbiology |volume=154 |issue=Pt 11 |pages=3480–90 |date=November 2008 |pmid=18957601 |doi=10.1099/mic.0.2007/016014-0 |url=}}
- {{cite journal |vauthors=Queck SY, Jameson-Lee M, Villaruz AE, etal |title=RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus |journal=Mol. Cell |volume=32 |issue=1 |pages=150–8 |date=October 2008 |pmid=18851841 |pmc=2575650 |doi=10.1016/j.molcel.2008.08.005 |url=}}
- {{cite journal |vauthors=Simonetti O, Cirioni O, Ghiselli R, etal |title=RNAIII-Inhibiting Peptide Enhances Healing of Wounds Infected with Methicillin-Resistant Staphylococcus aureus |journal=Antimicrob. Agents Chemother. |volume=52 |issue=6 |pages=2205–11 |date=June 2008 |pmid=18391046 |pmc=2415788 |doi=10.1128/AAC.01340-07 |url=}}
- {{cite journal |vauthors=Korem M, Gov Y, Kiran MD, Balaban N |title=Transcriptional Profiling of Target of RNAIII-Activating Protein, a Master Regulator of Staphylococcal Virulence |journal=Infect. Immun. |volume=73 |issue=10 |pages=6220–8 |date=October 2005 |pmid=16177293 |pmc=1230921 |doi=10.1128/IAI.73.10.6220-6228.2005 |url=}}
- {{cite journal |vauthors=Han YH, Kim YG, Kim DY, Ha SC, Lokanath NK, Kim KK |title=The target of RNAIII-activating protein (TRAP) from Staphylococcus aureus: purification, crystallization and preliminary X-ray analysis |journal=Biochim. Biophys. Acta |volume=1748 |issue=1 |pages=134–6 |date=April 2005 |pmid=15752702 |doi=10.1016/j.bbapap.2004.11.021 |url=}}
- {{cite journal |vauthors=Huntzinger E, Boisset S, Saveanu C, etal |title=Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression |journal=EMBO J. |volume=24 |issue=4 |pages=824–35 |date=February 2005 |pmid=15678100 |pmc=549626 |doi=10.1038/sj.emboj.7600572 |url=}}
- {{cite journal|last=Chabelskaya|first=S|author2=Bordeau, V |author3=Felden, B |title=Dual RNA regulatory control of a Staphylococcus aureus virulence factor.|journal=Nucleic Acids Research|date=Apr 1, 2014|volume=42|issue=8|pages=4847–58|pmid=24510101|doi=10.1093/nar/gku119|pmc=4005698}}
External links- {{Rfam|id=RF00503|name=RNAIII}}
{{molecular-cell-biology-stub}} 1 : Non-coding RNA |