| 词条 | Roseophilin |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 464383657 | ImageFile=Roseophilin.png | ImageSize=150px | IUPACName=15-[5-(3-Chloro-1H-pyrrol-2-yl)-3-methoxy-furan-2-yl]-13-isopropyl-2-aza-tricyclo[10.2.1.13,14]hexadeca-1(15),2-triene | OtherNames= |Section1={{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4578301 | InChI = 1/C27H33ClN2O2/c1-16(2)23-18-11-9-7-5-4-6-8-10-17-14-19(23)25(30-17)24(18)27-22(31-3)15-21(32-27)26-20(28)12-13-29-26/h12-16,18,23,30H,4-11H2,1-3H3/b26-21-,27-24- | InChIKey = XEQIXGXEBJYNMG-OLPWBVPVBQ | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C27H33ClN2O2/c1-16(2)23-18-11-9-7-5-4-6-8-10-17-14-19(23)25(30-17)24(18)27-22(31-3)15-21(32-27)26-20(28)12-13-29-26/h12-16,18,23,30H,4-11H2,1-3H3/b26-21-,27-24- | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = XEQIXGXEBJYNMG-OLPWBVPVSA-N | CASNo_Ref = {{cascite|changed|??}} | CASNo=142386-38-7 | PubChem=5467324 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1945189 | SMILES = CC(C)[C@H]1[C@@H]\\2CCCCCCCCC3=CC1=C(/C2=C\\4/C(=C/C(=C/5\\C(=CC=N5)Cl)/O4)OC)N3 }} |Section2={{Chembox Properties | Formula=C27H33ClN2O2 | MolarMass=453.02 g/mol | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }} Roseophilin is an antibiotic isolated from Streptomyces griscovirides shown to have antitumor activity.[1] The chemical structure can be considered in terms of two components, a macrotricyclic segment and a heterocyclic side-chain. Several laboratory syntheses of roseophilin (e.g., those of Trost, Fürstner, Salamone) are based upon the Paal-Knorr synthesis, and two others are based on the Nazarov cyclization reaction (those of Tius, Frontier). References1. ^{{cite journal|first=|year=2003|title=Chemistry and Biology of Roseophilin and the Prodigiosin Alkaloids: A Survey of the Last 2500 Years|url=|journal=Angew. Chem. Int. Ed.|volume=42|pages=3582–3603|via=|author=Fürstner, A.|doi=10.1002/anie.200300582}} {{antibiotic-stub}} 5 : Antibiotics|Pyrroles|Furans|Chloroarenes|Phenol ethers |
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