RS2 may refer to:

• Audi RS2 Avant, high-performance estate car/station wagon, jointly developed by Audi and Porsche
• 'RuneScape 2', a past update to the online game RuneScape
• ALCO RS-2, a diesel-electric locomotive built by Alco-GE.
• Romancing SaGa 2, video game
• RS2, an album by Canadian bass guitarist and singer-songwriter Rhonda Smith
• RS2 Software, a Maltese software company which provides payment solutions
• Windows 10 Redstone 2

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