“R-type calcium channel”的意思、由来-开放百科全书

The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α₁ subunit forms the pore through which calcium enters the cell and determines most of the channel's properties. This α₁ subunit is also known as the calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav_2.3 which in humans is encoded by the CACNA1E gene.^[1]^[2]^[3]

They are strongly expressed in cortex, hippocampus, striatum, amygdala and interpeduncular nucleus.^[4]

They are poorly understood, but like Q-type calcium channels, they appear to be present in cerebellar granule cells. They have a high threshold of activation and relatively slow kinetics.

References

1. ^{{cite web | title = Entrez Gene: CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=777 | access-date = }}
2. ^{{cite journal | vauthors = Soong TW, Stea A, Hodson CD, Dubel SJ, Vincent SR, Snutch TP | title = Structure and functional expression of a member of the low voltage-activated calcium channel family | journal = Science | volume = 260 | issue = 5111 | pages = 1133–6 | date = May 1993 | pmid = 8388125 | doi = 10.1126/science.8388125 }}
3. ^{{cite journal | vauthors = Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J | title = International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 411–25 | date = December 2005 | pmid = 16382099 | doi = 10.1124/pr.57.4.5 }}
4. ^{{cite journal | vauthors = Parajuli LK, Nakajima C, Kulik A, Matsui K, Schneider T, Shigemoto R, Fukazawa Y | title = Quantitative regional and ultrastructural localization of the Ca(v)2.3 subunit of R-type calcium channel in mouse brain | journal = The Journal of Neuroscience | volume = 32 | issue = 39 | pages = 13555–67 | date = September 2012 | pmid = 23015445 | doi = 10.1523/jneurosci.1142-12.2012 }}

Further reading

{{cite journal | vauthors = McNaughton NC, Green PJ, Randall AD | title = Inhibition of human alpha1E subunit-mediated ca2+ channels by the antipsychotic agent chlorpromazine | journal = Acta Physiologica Scandinavica | volume = 173 | issue = 4 | pages = 401–8 | date = December 2001 | pmid = 11903132 | doi = 10.1046/j.1365-201X.2001.00914.x }}

{{cite journal | vauthors = Berrou L, Klein H, Bernatchez G, Parent L | title = A specific tryptophan in the I-II linker is a key determinant of beta-subunit binding and modulation in Ca(V)2.3 calcium channels | journal = Biophysical Journal | volume = 83 | issue = 3 | pages = 1429–42 | date = September 2002 | pmid = 12202369 | pmc = 1302242 | doi = 10.1016/S0006-3495(02)73914-3 }}

{{cite journal | vauthors = Raybaud A, Baspinar EE, Dionne F, Dodier Y, Sauvé R, Parent L | title = The role of distal S6 hydrophobic residues in the voltage-dependent gating of CaV2.3 channels | journal = The Journal of Biological Chemistry | volume = 282 | issue = 38 | pages = 27944–52 | date = September 2007 | pmid = 17660294 | doi = 10.1074/jbc.M703895200 }}

{{cite journal | vauthors = Toro-Castillo C, Thapliyal A, Gonzalez-Ochoa H, Adams BA, Meza U | title = Muscarinic modulation of Cav2.3 (R-type) calcium channels is antagonized by RGS3 and RGS3T | journal = American Journal of Physiology. Cell Physiology | volume = 292 | issue = 1 | pages = C573–80 | date = January 2007 | pmid = 16855219 | doi = 10.1152/ajpcell.00219.2006 }}

{{cite journal | vauthors = Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J | title = International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 411–25 | date = December 2005 | pmid = 16382099 | doi = 10.1124/pr.57.4.5 }}

{{cite journal | vauthors = Kang HW, Moon HJ, Joo SH, Lee JH | title = Histidine residues in the IS3-IS4 loop are critical for nickel-sensitive inhibition of the Cav2.3 calcium channel | journal = FEBS Letters | volume = 581 | issue = 30 | pages = 5774–80 | date = December 2007 | pmid = 18037383 | doi = 10.1016/j.febslet.2007.11.045 }}

{{cite journal | vauthors = Natrajan R, Little SE, Reis-Filho JS, Hing L, Messahel B, Grundy PE, Dome JS, Schneider T, Vujanic GM, Pritchard-Jones K, Jones C | title = Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors | journal = Clinical Cancer Research | volume = 12 | issue = 24 | pages = 7284–93 | date = December 2006 | pmid = 17189400 | doi = 10.1158/1078-0432.CCR-06-1567 }}

{{cite journal | vauthors = Holmkvist J, Tojjar D, Almgren P, Lyssenko V, Lindgren CM, Isomaa B, Tuomi T, Berglund G, Renström E, Groop L | title = Polymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion | journal = Diabetologia | volume = 50 | issue = 12 | pages = 2467–75 | date = December 2007 | pmid = 17934712 | doi = 10.1007/s00125-007-0846-2 }}

{{cite journal | vauthors = Nyholt DR, LaForge KS, Kallela M, Alakurtti K, Anttila V, Färkkilä M, Hämaläinen E, Kaprio J, Kaunisto MA, Heath AC, Montgomery GW, Göbel H, Todt U, Ferrari MD, Launer LJ, Frants RR, Terwindt GM, de Vries B, Verschuren WM, Brand J, Freilinger T, Pfaffenrath V, Straube A, Ballinger DG, Zhan Y, Daly MJ, Cox DR, Dichgans M, van den Maagdenberg AM, Kubisch C, Martin NG, Wessman M, Peltonen L, Palotie A | title = A high-density association screen of 155 ion transport genes for involvement with common migraine | journal = Human Molecular Genetics | volume = 17 | issue = 21 | pages = 3318–31 | date = November 2008 | pmid = 18676988 | pmc = 2566523 | doi = 10.1093/hmg/ddn227 }}

{{cite journal | vauthors = Suzuki T, Delgado-Escueta AV, Aguan K, Alonso ME, Shi J, Hara Y, Nishida M, Numata T, Medina MT, Takeuchi T, Morita R, Bai D, Ganesh S, Sugimoto Y, Inazawa J, Bailey JN, Ochoa A, Jara-Prado A, Rasmussen A, Ramos-Peek J, Cordova S, Rubio-Donnadieu F, Inoue Y, Osawa M, Kaneko S, Oguni H, Mori Y, Yamakawa K | title = Mutations in EFHC1 cause juvenile myoclonic epilepsy | journal = Nature Genetics | volume = 36 | issue = 8 | pages = 842–9 | date = August 2004 | pmid = 15258581 | doi = 10.1038/ng1393 }}

{{cite journal | vauthors = Hainsworth AH, McNaughton NC, Pereverzev A, Schneider T, Randall AD | title = Actions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents | journal = European Journal of Pharmacology | volume = 467 | issue = 1–3 | pages = 77–80 | date = April 2003 | pmid = 12706458 | doi = 10.1016/S0014-2999(03)01625-X }}

{{cite journal | vauthors = Kamp MA, Krieger A, Henry M, Hescheler J, Weiergräber M, Schneider T | title = Presynaptic 'Ca2.3-containing' E-type Ca channels share dual roles during neurotransmitter release | journal = The European Journal of Neuroscience | volume = 21 | issue = 6 | pages = 1617–25 | date = March 2005 | pmid = 15845089 | doi = 10.1111/j.1460-9568.2005.03984.x }}

{{cite journal | vauthors = Berrou L, Bernatchez G, Parent L | title = Molecular determinants of inactivation within the I-II linker of alpha1E (CaV2.3) calcium channels | journal = Biophysical Journal | volume = 80 | issue = 1 | pages = 215–28 | date = January 2001 | pmid = 11159396 | pmc = 1301227 | doi = 10.1016/S0006-3495(01)76008-0 }}

{{cite journal | vauthors = Meza U, Thapliyal A, Bannister RA, Adams BA | title = Neurokinin 1 receptors trigger overlapping stimulation and inhibition of CaV2.3 (R-type) calcium channels | journal = Molecular Pharmacology | volume = 71 | issue = 1 | pages = 284–93 | date = January 2007 | pmid = 17050807 | doi = 10.1124/mol.106.028530 }}

{{cite journal | vauthors = Bernatchez G, Sauvé R, Parent L | title = State-dependent inhibition of inactivation-deficient Ca(V)1.2 and Ca(V)2.3 channels by mibefradil | journal = The Journal of Membrane Biology | volume = 184 | issue = 2 | pages = 143–59 | date = November 2001 | pmid = 11719851 | doi = 10.1007/s00232-001-0083-4 }}

{{cite journal | vauthors = Pereverzev A, Leroy J, Krieger A, Malécot CO, Hescheler J, Pfitzer G, Klöckner U, Schneider T | title = Alternate splicing in the cytosolic II-III loop and the carboxy terminus of human E-type voltage-gated Ca(2+) channels: electrophysiological characterization of isoforms | journal = Molecular and Cellular Neurosciences | volume = 21 | issue = 2 | pages = 352–65 | date = October 2002 | pmid = 12401453 | doi = 10.1006/mcne.2002.1179 }}

{{cite journal | vauthors = Fernandez F, Curtain RP, Colson NJ, Ovcaric M, MacMillan J, Griffiths LR | title = Association analysis of chromosome 1 migraine candidate genes | journal = BMC Medical Genetics | volume = 8 | pages = 57 | date = August 2007 | pmid = 17727731 | pmc = 2034370 | doi = 10.1186/1471-2350-8-57 }}

{{cite journal | vauthors = Vajna R, Klöckner U, Pereverzev A, Weiergräber M, Chen X, Miljanich G, Klugbauer N, Hescheler J, Perez-Reyes E, Schneider T | title = Functional coupling between 'R-type' Ca2+ channels and insulin secretion in the insulinoma cell line INS-1 | journal = European Journal of Biochemistry | volume = 268 | issue = 4 | pages = 1066–75 | date = February 2001 | pmid = 11179973 | doi = 10.1046/j.1432-1327.2001.01969.x }}

{{cite journal | vauthors = Muller YL, Hanson RL, Zimmerman C, Harper I, Sutherland J, Kobes S, Knowler WC, Bogardus C, Baier LJ | title = Variants in the Ca V 2.3 (alpha 1E) subunit of voltage-activated Ca2+ channels are associated with insulin resistance and type 2 diabetes in Pima Indians | journal = Diabetes | volume = 56 | issue = 12 | pages = 3089–94 | date = December 2007 | pmid = 17720895 | doi = 10.2337/db07-0587 }}

References

Further reading

External links