| 词条 | RU-28362 |
| 释义 |
| ImageFile = RU28362_molecular_structure.png | ImageSize = 250 | ImageAlt = Molecular structure of RU28362 | IUPACName = 11β,17β-Dihydroxy-6-methyl-17α-(1-propynyl)androsta-1,4,6-trien-3-one | OtherNames = |Section1={{Chembox Identifiers | IUPHAR_ligand = 3445 | CASNo = 74915-64-3 | PubChem = 123790 | InChI = 1S/C23H28O3/c1-5-8-23(26)10-7-17-16-11-14(2)18-12-15(24)6-9-21(18,3)20(16)19(25)13-22(17,23)4/h6,9,11-12,16-17,19-20,25-26H,7,10,13H2,1-4H3/t16-,17-,19-,20+,21-,22-,23-/m0/s1 | InChIKey = UFZKDKHLKHEFGA-ZFTCBNFESA-N | SMILES = CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2C=C(C4=CC(=O)C=C[C@]34C)C)O)C)O | ChemSpiderID = 110341 | InChI2 = 1/C23H28O3/c1-5-8-23(26)10-7-17-16-11-14(2)18-12-15(24)6-9-21(18,3)20(16)19(25)13-22(17,23)4/h6,9,11-12,16-17,19-20,25-26H,7,10,13H2,1-4H3/t16-,17-,19-,20+,21-,22-,23-/m0/s1 | InChIKey2 = UFZKDKHLKHEFGA-ZFTCBNFEBV | StdInChI = 1S/C23H28O3/c1-5-8-23(26)10-7-17-16-11-14(2)18-12-15(24)6-9-21(18,3)20(16)19(25)13-22(17,23)4/h6,9,11-12,16-17,19-20,25-26H,7,10,13H2,1-4H3/t16-,17-,19-,20+,21-,22-,23-/m0/s1 | StdInChIKey = UFZKDKHLKHEFGA-ZFTCBNFESA-N}} |Section2={{Chembox Properties | C=23| H=28| O=3 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}RU-28362 is a synthetic androstane glucocorticoid that was developed by Roussel Uclaf. It is a selective agonist of the glucocorticoid receptor (corticoid type II receptor), but not of the mineralocorticoid receptor (corticoid type I receptor).[1][2] A similar compound is dexamethasone that also selectively binds to the glucocorticoid receptor with high affinity. This is in contrast to the natural steroid hormones cortisol or corticosterone, which bind to both of the corticosteroid receptors, though they bind to the mineralocorticoid receptor with greater affinity.[3] See also
References1. ^{{cite journal |vauthors=Woolley C, Gould E, Sakai R, Spencer R, McEwen B |title=Effects of aldosterone or RU28362 treatment on adrenalectomy-induced cell death in the dentate gyrus of the adult rat |journal=Brain Res |volume=554 |issue=1–2 |pages=312–5 |year=1991 |pmid=1933312 |doi=10.1016/0006-8993(91)90207-C}} {{Glucocorticoid receptor modulators}}{{DEFAULTSORT:Ru28362}}{{steroid-stub}}2. ^{{cite journal |vauthors=Wong D, Lesage A, Siddall B, Funder J |title=Glucocorticoid regulation of phenylethanolamine N-methyltransferase in vivo |journal=FASEB J |volume=6 |issue=14 |pages=3310–5 |year=1992 |pmid=1426768}} 3. ^{{cite journal|last=Arriza|first=JL|author2=Simerly, RB |author3=Swanson, LW |author4= Evans, RM |title=The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response.|journal=Neuron|date=November 1988|volume=1|issue=9|pages=887–900|pmid=2856104|doi=10.1016/0896-6273(88)90136-5}} 2 : Androstanes|Glucocorticoids |
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