“S100A2”的意思、由来-开放百科全书

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer.^[2]

References

1. ^{{cite journal |vauthors=Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW | title = Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 14 | pages = 6547–51 |date=Aug 1993 | pmid = 8341667 | pmc = 46969 | doi =10.1073/pnas.90.14.6547 }}
2. ^{{cite web | title = Entrez Gene: S100A2 S100 calcium binding protein A2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6273| accessdate = }}

Further reading

{{cite journal |vauthors=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134–40 |year= 1996 |pmid= 8701470 |doi= 10.1016/S0968-0004(96)80167-8}}

{{cite journal | author=Rasmussen HH |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=10.1002/elps.11501301199 |name-list-format=vanc| author2=van Damme J | author3=Puype M | display-authors=3 | last4=Gesser | first4=Borbala | last5=Celis | first5=Julio E. | last6=Vandekerckhove | first6=Joël }}

{{cite journal | author=Lee SW |title=Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 6 |pages= 2504–8 |year= 1992 |pmid= 1372446 |doi=10.1073/pnas.89.6.2504 | pmc=48687 |name-list-format=vanc| author2=Tomasetto C | author3=Swisshelm K | display-authors=3 | last4=Keyomarsi | first4=K | last5=Sager | first5=R }}

{{cite journal | author=Schäfer BW |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family |journal=Genomics |volume=25 |issue= 3 |pages= 638–43 |year= 1995 |pmid= 7759097 |doi=10.1016/0888-7543(95)80005-7 |name-list-format=vanc| author2=Wicki R | author3=Engelkamp D | display-authors=3 | last4=Mattei | first4=Marie-Geneviève | last5=Heizmann | first5=Claus W. }}

{{cite journal | author=Gimona M |title=Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins |journal=J. Cell Sci. |volume=110 |issue= 5|pages= 611–21 |year= 1997 |pmid= 9092943 |doi= |name-list-format=vanc| author2=Lando Z | author3=Dolginov Y | display-authors=3 | last4=Vandekerckhove | first4=J | last5=Kobayashi | first5=R | last6=Sobieszek | first6=A | last7=Helfman | first7=DM }}

{{cite journal | author=Böni R |title=Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions |journal=Br. J. Dermatol. |volume=137 |issue= 1 |pages= 39–43 |year= 1997 |pmid= 9274623 |doi=10.1111/j.1365-2133.1997.tb03698.x |name-list-format=vanc| author2=Burg G | author3=Doguoglu A | display-authors=3 | last4=Ilg | first4=E.C. | last5=Schäfer | first5=B.W. | last6=Müller | first6=B. | last7=Heizmann | first7=C.W. }}

{{cite journal |vauthors=Groves P, Finn BE, Kuźnicki J, Forsén S |title=A model for target protein binding to calcium-activated S100 dimers |journal=FEBS Lett. |volume=421 |issue= 3 |pages= 175–9 |year= 1998 |pmid= 9468301 |doi=10.1016/S0014-5793(97)01535-4 }}

{{cite journal | author=Wicki R |title=Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation |journal=Cell Calcium |volume=22 |issue= 4 |pages= 243–54 |year= 1998 |pmid= 9481475 |doi=10.1016/S0143-4160(97)90063-4 |name-list-format=vanc| author2=Franz C | author3=Scholl FA | display-authors=3 | last4=Heizmann | first4=Claus W. | last5=Schäfer | first5=Beat W. }}

{{cite journal | author=Franz C |title=Binding of Ca2+ and Zn2+ to human nuclear S100A2 and mutant proteins |journal=J. Biol. Chem. |volume=273 |issue= 30 |pages= 18826–34 |year= 1998 |pmid= 9668057 |doi=10.1074/jbc.273.30.18826 |name-list-format=vanc| author2=Durussel I | author3=Cox JA | display-authors=3 | last4=Schäfer | first4=BW | last5=Heizmann | first5=CW }}

{{cite journal | author=Mueller A |title=Subcellular distribution of S100 proteins in tumor cells and their relocation in response to calcium activation |journal=Histochem. Cell Biol. |volume=111 |issue= 6 |pages= 453–9 |year= 1999 |pmid= 10429967 |doi=10.1007/s004180050381 |name-list-format=vanc| author2=Bächi T | author3=Höchli M | display-authors=3 | last4=SchäFer | first4=Beat W. | last5=Heizmann | first5=C. W. }}

{{cite journal |vauthors=Stradal TB, Troxler H, Heizmann CW, Gimona M |title=Mapping the zinc ligands of S100A2 by site-directed mutagenesis |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13219–27 |year= 2000 |pmid= 10788426 |doi=10.1074/jbc.275.18.13219 }}

{{cite journal | author=Hoyaux D |title=S100 proteins in Corpora amylacea from normal human brain |journal=Brain Res. |volume=867 |issue= 1–2 |pages= 280–8 |year= 2000 |pmid= 10837826 |doi=10.1016/S0006-8993(00)02393-3 |name-list-format=vanc| author2=Decaestecker C | author3=Heizmann CW | display-authors=3 | last4=Vogl | first4=Thomas | last5=Schäfer | first5=Beat W | last6=Salmon | first6=Isabelle | last7=Kiss | first7=Robert | last8=Pochet | first8=Roland }}

{{cite journal | author=Deshpande R |title=Biochemical characterization of S100A2 in human keratinocytes: subcellular localization, dimerization, and oxidative cross-linking |journal=J. Invest. Dermatol. |volume=115 |issue= 3 |pages= 477–85 |year= 2000 |pmid= 10951287 |doi= 10.1046/j.1523-1747.2000.00078.x |name-list-format=vanc| author2=Woods TL | author3=Fu J | display-authors=3 | last4=Zhang | first4=Tong | last5=Stoll | first5=Stefan W. | last6=Elder | first6=James T. }}

{{cite journal | author=Nagy N |title=The Ca2+-binding S100A2 protein is differentially expressed in epithelial tissue of glandular or squamous origin |journal=Histol. Histopathol. |volume=17 |issue= 1 |pages= 123–30 |year= 2002 |pmid= 11813862 |doi= |name-list-format=vanc| author2=Hoyaux D | author3=Gielen I | display-authors=3 | last4=Schäfer | first4=BW | last5=Pochet | first5=R | last6=Heizmann | first6=CW | last7=Kiss | first7=R | last8=Salmon | first8=I | last9=Decaestecker | first9=C }}

{{cite journal | author=Kyriazanos ID |title=Expression and prognostic significance of S100A2 protein in squamous cell carcinoma of the esophagus |journal=Oncol. Rep. |volume=9 |issue= 3 |pages= 503–10 |year= 2002 |pmid= 11956617 |doi= 10.3892/or.9.3.503|name-list-format=vanc| author2=Tachibana M | author3=Dhar DK | display-authors=3 | last4=Shibakita | first4=M | last5=Ono | first5=T | last6=Kohno | first6=H | last7=Nagasue | first7=N }}

{{cite journal |vauthors=Zhang T, Woods TL, Elder JT |title=Differential responses of S100A2 to oxidative stress and increased intracellular calcium in normal, immortalized, and malignant human keratinocytes |journal=J. Invest. Dermatol. |volume=119 |issue= 5 |pages= 1196–201 |year= 2003 |pmid= 12445212 |doi= 10.1046/j.1523-1747.2002.19520.x }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Hibi K |title=Identification of S100A2 as a target of the DeltaNp63 oncogenic pathway |journal=Clin. Cancer Res. |volume=9 |issue= 11 |pages= 4282–5 |year= 2004 |pmid= 14519656 |doi= |name-list-format=vanc| author2=Fujitake S | author3=Takase T | display-authors=3 | last4=Kodera | first4=Y | last5=Ito | first5=K | last6=Akiyama | first6=S | last7=Shirane | first7=M | last8=Nakao | first8=A }}

1 : S100 proteins