“(S)-2-methylmalate dehydratase”的意思、由来-开放百科全书

词条

(S)-2-methylmalate dehydratase

释义

References

{{enzyme
| Name = (S)-2-methylmalate dehydratase
| EC_number = 4.2.1.34
| CAS_number = 9027-94-5
| IUBMB_EC_number = 4/2/1/34
| GO_code = 0047510
| image =
| width =
| caption =
}}

In enzymology, a (S)-2-methylmalate dehydratase ({{EC number|4.2.1.34}}) is an enzyme that catalyzes the chemical reaction

(S)-2-methylmalate 2-methylfumarate + H₂O

Hence, this enzyme has one substrate, (S)-2-methylmalate, and two products, 2-methylfumarate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (S)-2-methylmalate hydro-lyase (2-methylfumarate-forming). Other names in common use include mesaconate hydratase, (+)-citramalate hydro-lyase, L-citramalate hydrolase, citramalate dehydratase, (+)-citramalic hydro-lyase, mesaconate mesaconase, mesaconase, and (S)-2-methylmalate hydro-lyase. This enzyme participates in c5-branched dibasic acid metabolism. In addition, the family of lyases which is also an enzyme catalyzes the breaking the elimination reaction of the variety of amounts of chemical bonds from hydrolysis (a substitution reaction ) and oxidation, which forms a new double bond or a new ring structure.^[1]

References

1. ^"Blair AH, Barker HA (1966). , Wang CC, Barker HA (1969). There are also other enzymes in international Union of Biochemistry and Molecular Biology.

{{cite journal |vauthors=Blair AH, Barker HA | date = 1966 | title = Assay and purification of (+)-citramalate hydro-lyase components from Clostridium tetanomorphum | journal = J. Biol. Chem. | volume = 241 | pages = 400–8 | pmid = 5903732 | issue = 2 }}
{{cite journal |vauthors=Wang CC, Barker HA | date = 1969 | title = Purification and properties of L-citramalate hydrolyase | journal = J. Biol. Chem. | volume = 244 | pages = 2516–26 | pmid = 5769987 | issue = 10 }}

2 : EC 4.2.1|Enzymes of unknown structure

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