Saint-Leu may refer to:

In France:

• Saint-Leu, Réunion, Réunion department
• Saint-Leu-d'Esserent, Oise department
• Saint-Leu-la-Forêt, Val-d'Oise department
• Huby-Saint-Leu, Pas-de-Calais department
• Villers-sous-Saint-Leu, Oise department

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