“Scyllo-inosamine-4-phosphate amidinotransferase”的意思、由来-开放百科全书

词条

Scyllo-inosamine-4-phosphate amidinotransferase

释义

Structural studies
References

{{enzyme
| Name = scyllo-inosamine-4-phosphate amidinotransferase
| EC_number = 2.1.4.2
| CAS_number = 52227-63-1
| IUBMB_EC_number = 2/1/4/2
| GO_code = 0015069
| image =
| width =
| caption =
}}

In enzymology, a scyllo-inosamine-4-phosphate amidinotransferase ({{EC number|2.1.4.2}}) is an enzyme that catalyzes the chemical reaction

L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate

Thus, the two substrates of this enzyme are L-arginine and 1-amino-1-deoxy-scyllo-inositol 4-phosphate, whereas its two products are L-ornithine and 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the amidinotransferases. The systematic name of this enzyme class is L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase. Other names in common use include L-arginine:inosamine-P-amidinotransferase, inosamine-P amidinotransferase, L-arginine:inosamine phosphate amidinotransferase, and inosamine-phosphate amidinotransferase. This enzyme participates in streptomycin biosynthesis.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|1BWD}}.

References

{{cite journal | vauthors = Walker MS, Walker JB | date = 1966 | title = Enzymic studies on the biosynthesis of streptomycin, transamidation of inosamine and streptamine derivatives | journal = J. Biol. Chem. | volume = 241 | pages = 1262–1269 }}

2 : EC 2.1.4|Enzymes of known structure

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