“Scytalone dehydratase”的意思、由来-开放百科全书

词条

Scytalone dehydratase

释义

Structural studies
References

{{enzyme
| Name = scytalone dehydratase
| EC_number = 4.2.1.94
| CAS_number =
| IUBMB_EC_number = 4/2/1/94
| GO_code = 0030411
| image =
| width =
| caption =
}}

In enzymology, a scytalone dehydratase ({{EC number|4.2.1.94}}) is an enzyme that catalyzes the chemical reaction

scytalone 1,3,8-trihydroxynaphthalene + H₂O

Hence, this enzyme has one substrate, scytalone, and two products, 1,3,8-trihydroxynaphthalene and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming). This enzyme is also called scytalone 7,8-hydro-lyase.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1IDP}}, {{PDB link|1STD}}, {{PDB link|2STD}}, {{PDB link|3STD}}, {{PDB link|4STD}}, {{PDB link|5STD}}, {{PDB link|6STD}}, and {{PDB link|7STD}}.

References

{{cite journal | vauthors = Butler MJ, Lazarovits G, Higgins VJ, Lachance MA | date = 1988 | title = Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi | journal = Exp. Mycol. | volume = 12 | issue = 4 | pages = 367–376 | doi = 10.1016/0147-5975(88)90028-X }}
{{cite journal | vauthors = Tajima S, Kubo Y, Furusawa I, Shishiyama J | date = 1989 | title = Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus | journal = Exp. Mycol. | volume = 13 | pages = 69 | doi = 10.1016/0147-5975(89)90009-1 }}
{{cite journal |author1 = Wheeler MH |author2 =Greenblatt GA | date = 1988 | title = The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease | journal = Exp. Mycol. | volume = 12 | issue = 2 | pages = 151–160 | doi = 10.1016/0147-5975(88)90004-7 }}

2 : EC 4.2.1|Enzymes of known structure

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