Sean Hayes may refer to:

• Seán Hayes (Cork politician) (died 1941), otherwise known as John Hayes, Sinn Féin member of the 1st Dáil Éireann, and the 2nd and 3rd
• Seán Hayes (Tipperary politician) (1890–1968), Fianna Fáil TD for Tipperary, later a senator
• Seán Hayes (Gaelic footballer) (born 1960), retired Gaelic footballer who played for Cork
• Sean Hayes (musician) (born 1969), American singer-songwriter
• Sean Hayes (actor) (born 1970), American actor, best known for his role as Jack McFarland in the sitcom Will & Grace
• Sean Clements and Hayes Davenport, American comedians and writers, hosts of the Hollywood Handbook podcast.

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