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词条 Sigma-Aldrich
释义

  1. History

     Early history   Acquisitions    1970s    1980s    1990s    2000s  

  2. Key numbers

  3. Subsidiaries

  4. Distribution

  5. Current leadership

  6. References

  7. External links

{{primary sources|date=September 2013}}{{Infobox company|
| name = Sigma-Aldrich Corporation
| logo = Sigma-Aldrich logo.svg
| logo_size = 200px
| caption =
| type = subsidiary of Merck KGaA
| traded_as = {{NASDAQ was|SIAL}}
| industry = chemistry and biotechnology
| location = St. Louis, Missouri
United States
| foundation = August 1975
| key_people = Udit Batra {{small|(CEO)}}[1]
| num_employees = more than 9,600
| products = life science technologies and specialty chemicals
| revenue = US$ 2.7 billion (2014)[2]
| equity = US$ 3.13 billion (2014)[2]
| assets = US$ 4.19 billion (2014)[2]
| net_income = US$ 500.0 million (2014)[2]
| operating_income = US$ 681.0 million (2014)[2]
| parent = Merck KGaA (100%)[3]
| homepage = {{URL|https://www.sigmaaldrich.com}}
}}

Sigma-Aldrich Corporation is an American chemical, life science and biotechnology company owned by Merck KGaA.

Created by the 1975 merger of Sigma Chemical Company and Aldrich Chemical Company, Sigma-Aldrich since grew through various acquisitions until it had over 9,600 employees and was listed on the Fortune 1000 at the time of its acquisition by Merck. The company is headquartered in St. Louis and has operations in approximately 40 countries.[4]

In September 2014, the German company Merck KGaA announced that it would be acquiring Sigma-Aldrich for $17 billion.[5] The acquisition was completed in November 2015 and Sigma-Aldrich became a subsidiary of Merck KGaA. The company is currently a part of Merck's life science business and in combination with Merck's earlier acquired Millipore, operates as MilliporeSigma.[6][7]

History

Sigma Chemical Company of St. Louis and Aldrich Chemical Company of Milwaukee were both American specialty chemical companies when they merged in August 1975. The company grew throughout the 1980s and 1990s, with significant expansion in facilities, acquisitions and diversification into new market sectors.

Early history

  • 1935 – Midwest Consultants was founded in St Louis by the Fischer brothers.
    • 1946 – Sigma was formed from Midwest Consultants and manufactured just adenosine triphosphate. They were the first to manufacture pure ATP.[8]
    • 1972 – Sigma's IPO[9]
  • 1951 – Aldrich founded in Milwaukee by Alfred Bader and Jack Eisendrath and manufactured just 1-methyl-3-nitro-1-nitrosoguanidine.
    • 1966 – Aldrich's IPO[10]
    • 1972 – Subsidiary Aldrich-Boranes launched to manufacture hydroboration products
  • 1975 – Merger of Sigma Chemical and Aldrich Chemical to created Sigma-Aldrich.[11] Their first year earned $43 million in sales.[12]
  • 1999 – Sigma-Aldrich reaches $1 billion in sales
  • 2005 – Announced membership in The RNAi Consortium[13]
  • 2014 – Merck KGaA announced that it would purchase Sigma-Aldrich for approx. $17 billion (€13.1 billion).[14][15]
  • November 3, 2014 – Sigma-Aldrich filed a definitive proxy statement with the U.S. Securities and Exchange Commission to hold a special investors meeting regarding approval for the sale to Merck KGaA.[16]

Acquisitions

1970s

  • 1978 – Makor Chemicals

1980s

  • 1984 – Pathfinder
  • 1986 – Bio Yeda, Bristol Organics
  • 1989 – Fluka Chemie AG (Swiss company founded in the 1950s) purchased for $39 million.

1990s

  • 1993 – Supelco, Inc. acquired to enter the chromatography market
  • 1994 – LabKemi AB
  • 1997 – Research Biochemicals International, Riedel-de-Haen, Techcares Systems, Carbolabs, YA Kemia
  • 1998 – Genosys

2000s

  • 2000 – First Medical Inc., Amelung GmbH, ARK Scientific
  • 2001 – ISOTEC (produces stable isotopes used in basic research and medical diagnostics)[17]
  • 2004 – Ultrafine (a supplier of contract manufacturing services for drug development), Tetrionics (a producer of high potency and cytotoxic active pharmaceutical ingredients)[18]
  • 2005 – JRH Biosciences,[19] an industrial supplier of cell culture products for the pharmaceutical and biotechnology industries; Proligo Group, a global supplier of genomics research tools
  • 2006 – Beijing Superior Chemicals,[20] Iropharm, Pharmorphix,[21] Advanced Separation Technologies[22] (manufacturer of products for chiral chromatography)
  • 2007 – Epichem[23] acquired to expand capabilities in materials sciences and semiconductor markets; Molecular Medicine BioServices acquired to provide large-scale viral manufacturing capabilities; announced alliance with Sangamo BioSciences to develop zinc finger-based laboratory research reagents
  • 2009 – ChemNavigator
  • 2010 – Cerilliant Corporation, ACE Animals
  • 2011 – Resource Technology Corp, Vetec Quimica Fina
  • 2012 – Research Organics Inc., BioReliance (a toxicology and veterinary diagnostics company); BioReliance had previously been acquired by Invitrogen and subsequently sold to Avista Capital Partners.[29]
  • 2014 – Cell Marque[24]
  • 2015 – Combined with EMD Millipore to make MilliporeSigma.{{cn|date=July 2018}}

Key numbers

Key numbers for Sigma-Aldrich.[2]

Revenues:[25]
  • $2.79 billion (2014)
Products:
  • 100,000 chemical products (46,000 manufactured)
  • 30,000 laboratory equipment products
Customers:
  • Approximately one million individual customers worldwide
  • 88,000 accounts
Geographies (% of 2008 sales):
  • United States 35%
  • Europe 43%
  • Canada, Asia Pacific, Latin America 22%

Subsidiaries

{{unreferenced section|date=November 2014}}

Aldrich is a supplier in the research and fine chemicals market. Aldrich provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science. Aldrich's chemicals catalog, the "Aldrich Catalog and Handbook" is often used as a handbook due to the inclusion of structures, physical data, and literature references.

Sigma is the Sigma-Aldrich's main biochemical supplier, with offerings including antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.

Sigma RBI produces specialized products for use in the field of cell signaling and neuroscience. Their offerings range from standard biochemical reagents to specialized research tools, including ligands for receptors and ion channels, enzyme inhibitors, phosphospecific antibodies, key signal transduction enzymes, and assay kits for cell signaling.

ISOTEC provides isotopically labeled products for protein structure determination, peptide synthesis, proteomics, metabolic research, magnetic resonance imaging, nuclear magnetic resonance, breath test substrates, agriculture, as well as gas and gas mixes.

Riedel-de Haën was incorporated with Sigma-Aldrich in 1999 and manufactures reagents and standards.

Supelco is the chromatography products branch of Sigma-Aldrich. It provides chromatography columns and related tools for environmental, government, food and beverage, pharmaceutical, biotechnology, medical and chemical laboratories; sample preparation products and chemical reference standards.

Sigma-Aldrich Fine Chemicals (SAFC) is the fine chemical supply branch of Sigma-Aldrich specializing in raw materials for cell culture products; customized services for raw materials, manufacturing of active pharmaceutical ingredients.

Sigma Life Science provides products such as custom DNA/RNA oligos; custom DNA and LNA probes; siRNA; isotopically-labelled peptides and peptide libraries.

Sigma Advanced Genetic Engineering (SAGE) Labs is a division within Sigma-Aldrich that specializes in genetic manipulation of in vivo systems for special research and development applications. It was formed in 2008 to investigate zinc finger nuclease technology and its application for disease research models. Located in St. Louis, Missouri, SAGE Labs have developed knockout rats for the study of human diseases and disorders (such as autism), which are sold for up to US$95,000. SAGE also announced its first successful effort in creating a "knockout rabbit".[26] Its facilities include a specific pathogen free, biosecure vivarium as well as research and development labs.

Carbolabs produces research quantities of chemicals produced by phosgenation reactions. The company was acquired in 1998.[27]

BioReliance provides testing and manufacturing services to pharmaceutical and biopharmaceutical companies that span the product cycle from early pre-clinical development to licensed production.

The company was acquired by Sigma Aldrich in January 2012.

Distribution

Sigma-Aldrich is located in 40 countries world-wide. In territories where they are not present, Sigma-Aldrich operates through a network of authorized distributors. A list of them can be found below:

  • Nigeria – Bristol Scientific Company - {{URL|www.bristolscientific.com}}[28]
  • Turkey – INTERLAB Laboratory Products - {{URL|http://www.interlab.com.tr/en}}[29]
  • Romania – Redox Lab Supplies SRL - {{URL|http://www.redox.ro}}[30]

The company also operates an eCommerce platform "which offers 24-hour delivery in major markets."[15]

Current leadership

Udit Batra became the CEO of MilliporeSigma in 2014. Batra led the merger of SigmaAldrich and Merck Millipore, closing in November 2015.

References

1. ^{{cite web|url=https://www.emdgroup.com/en/company/who-we-are/management/executive-board/udit-batra.html|title=Udit Batra; Member of the Executive Board, CEO Life Science|publisher=Merck}}
2. ^1 2 3 4 5 {{cite web|url=https://www.sec.gov/cgi-bin/viewer?action=view&cik=90185&accession_number=0000090185-15-000027&xbrl_type=v |title=SIGMA ALDRICH CORP (10-K), Consolidated Statements of Income |publisher=United States Securities and Exchange Commission |format=XBRL |date=February 12, 2015}}
3. ^{{cite web|url=http://www.emdmillipore.com/US/en/20151117_174251|title=Merck KGaA, Darmstadt, Germany, Completes Sigma-Aldrich Acquisition|publisher=Merck|format=XBRL|date=November 18, 2015}}
4. ^{{cite web|url=http://investor.sigmaaldrich.com/|title=Sigma-Aldrich Corporation – Investor Relations}}
5. ^{{cite web|url=http://news.emdgroup.com/N/0/553D2351699994CBC1257D5B0029982E/%24File/EMD20140922.pdf|title="Sigma-Aldrich, Merck KGaA Press Release, 22 Sept. 2014}}
6. ^{{Cite web |url=http://www.merckmillipore.com/DE/en/about-us/news-media-room/customer-letter/h2qb.qB.D88AAAFIGctSpp69,nav |title=Customer Letter |access-date=2016-01-04 |archive-url=https://web.archive.org/web/20160208120220/http://www.merckmillipore.com/DE/en/about-us/news-media-room/customer-letter/h2qb.qB.D88AAAFIGctSpp69,nav |archive-date=2016-02-08 |dead-url=yes |df= }}
7. ^About Us, EMD Millipore + Sigma-Aldrich = MilliporeSigma, The life science business of Merck KGaA, Darmstadt, Germany
8. ^{{cite web|url=http://www.sigmaaldrich.com/ifb/80_years/80_years.html#2/z|title=80 Years Fueling Scientific Discovery|author=|date=|website=sigmaaldrich.com}}
9. ^{{cite web|url=http://www.sigmaaldrich.com/ifb/80_years/80_years.html#5/z|title=80 Years Fueling Scientific Discovery|author=|date=|website=sigmaaldrich.com}}
10. ^{{cite web|url=http://www.sigmaaldrich.com/ifb/80_years/80_years.html#9/z|title=80 Years Fueling Scientific Discovery|author=|date=|website=sigmaaldrich.com}}
11. ^{{cite journal|journal=Funding-Universe|url=http://www.fundinguniverse.com/company-histories/SigmaAldrich-Corporation-Company-History.html|title=Funding Universe History of Sigma-Aldrich Corporation}}
12. ^{{cite web|url=http://www.sigmaaldrich.com/ifb/80_years/80_years.html#10/z|title=80 Years Fueling Scientific Discovery|author=|date=|website=sigmaaldrich.com}}
13. ^{{cite web|url=https://www.ncbi.nlm.nih.gov/projects/genome/probe/doc/DistrSigmaAldrich.shtml|title=NCBI on Sigma-Aldrich}}
14. ^{{cite news |url=https://www.reuters.com/article/2014/09/22/us-merck-sigma-aldrich-idUSKCN0HH1CK20140922 |author=Ludwig Burger |title=Germany's Merck to buy Sigma-Aldrich for $17 billion to boost lab supplies operation |publisher=Reuters |date=September 22, 2014 |accessdate=September 23, 2014}}
15. ^1 {{Cite news|url = |title = Merck KGaA to Acquire Sigma-Aldrich for $17B|last = Staff|first = |date = October 15, 2014|work = Genetic Engineering & Biotechnology News|access-date = |page = 10}}
16. ^{{cite web|title=Sigma-Aldrich Corporation Announces Filing Of Definitive Proxy Statement And Date Of Special Meeting Of Stockholders|url=http://investor.sigmaaldrich.com/releasedetail.cfm?ReleaseID=879879|archive-url=https://web.archive.org/web/20141228102947/http://investor.sigmaaldrich.com/releasedetail.cfm?ReleaseID=879879|archive-date=December 28, 2014|publisher=Acquire Media|accessdate=3 November 2014|deadurl=yes|df=}}
17. ^{{cite web|url=http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Isotec_Inc_from_Taiyo_Nippon_Sanso_Corp-291771|title=Sigma-Aldrich Corp acquires Isotec Inc from Taiyo Nippon Sanso Corp}}
18. ^{{cite web|url=http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Ultrafine-379839|title=Sigma-Aldrich Corp acquires Ultrafine}}
19. ^{{cite web|url=http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_JRH_Biosciences_Inc_from_CSL_Ltd-404688|title=Sigma-Aldrich Corp acquires JRH Biosciences Inc from CSL Ltd}}
20. ^{{cite web|url=http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Beijing_Superior_Chem_Instr-446229|title=Sigma-Aldrich Corp acquires Beijing Superior Chem & Instr}}
21. ^{{cite web|url=http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Pharmorphix_Ltd-453051|title=Sigma-Aldrich Corp acquires Pharmorphix Ltd}}
22. ^{{cite web|url=http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Advanced_Separation_Tech_Inc_from_Calgon_Carbon_Corp-457772|title=Sigma-Aldrich Corp acquires Advanced Separation Tech Inc from Calgon Carbon Corp}}
23. ^{{cite web|url=http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Epichem_Group_Ltd-471452|title=Sigma-Aldrich Corp acquires Epichem Group Ltd}}
24. ^{{cite web|url=http://www.sigmaaldrich.com/ifb/80_years/80_years.html#29/z|title=80 Years Fueling Scientific Discovery|author=|date=|website=sigmaaldrich.com}}
25. ^{{cite web|url=http://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma-Aldrich/General_Information/1/sigma-aldrich-corporate-fact-sheet.pdf |title=Sigma-Aldrich Corporate Fact Sheet}}
26. ^{{cite web|url=http://www.fastcompany.com/1751571/sages-latest-knockout-95000-lab-rats|title=SAGE's Latest Knockout: $95,000 Lab Rats|work=Fast Company}}
27. ^{{cite journal|journal=ICIS|url=http://www.icis.com/Articles/1998/06/01/60679/carbolabs-purchased.html|title=Carbolabs purchased}}
28. ^{{cite web|url=http://www.sigmaaldrich.com/customer-service/worldwide-offices/worldwide-offices2.html#nigeria|title=Distributor Nigeria}}
29. ^{{cite web|url=http://www.sigmaaldrich.com/customer-service/worldwide-offices/worldwide-offices2.html#Turkey|title=Distributor Turkey}}
30. ^{{cite web|url=http://www.sigmaaldrich.com/customer-service/worldwide-offices/worldwide-offices2.html#Romania|title=Distributor Romania}}
31. ^1 {{Citation |publication-date=12 April 2007 |title=Invitrogen Completes Divestiture of BioReliance |type=press release |publisher=Life Technologies |url=http://ir.lifetechnologies.com/releasedetail.cfm?ReleaseID=538948 |accessdate=11 Jan 2012 |archive-url=https://web.archive.org/web/20120330205627/http://ir.lifetechnologies.com/releasedetail.cfm?ReleaseID=538948 |archive-date=2012-03-30 |dead-url=yes |df= }}
[31]
}}

External links

{{Portal|Companies}}{{Commonscat-inline}}
  • Official website
  • [https://www.facebook.com/DiscoverMerck/ Comunidad Oficial Facebook LATAM - Merck Life Science]
  • [https://www.linkedin.com/company/DiscoverMerck/ Comunidad Linkedin LATAM - Merck Life Science]

7 : Companies formerly listed on NASDAQ|Research support companies|Chemical companies of the United States|Companies based in St. Louis|Biotechnology companies of the United States|2015 mergers and acquisitions|Companies formed by merger
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