| 词条 | Small Cajal body specific RNA 14 |
| 释义 |
| Name = Small Cajal body specific RNA 14 | image = RF00582.jpg | width = | caption = Predicted secondary structure and sequence conservation of SCARNA14 | Symbol = SCARNA14 | AltSymbols = snoU100 | Rfam = RF00582 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; snoRNA; scaRNA | Tax_domain = Eukaryota | GO = {{GO|0006396}} {{GO|0015030}} {{GO|0005730}} | SO = {{SO|0000275}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} In molecular biology, Small Cajal body specific RNA 14 (also known as scaRNA14 or U100) is a small nucleolar RNA found in Cajal bodies. scaRNAs are a specific class of small nucleolar RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1][2] U100 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure and the conserved H/ACA-box motifs.[3] U100 is the human orthologue of mouse H/ACA snoRNA MBII-201 which is also included in this family.[4] U100 is predicted to guide the pseudouridylation of U2 snRNA at residue U7.[5] References1. ^{{Cite journal | last1 = Darzacq | first1 = Xavier | last2 = Jády | first2 = Beáta E. | last3 = Verheggen | first3 = Céline | last4 = Kiss | first4 = Arnold M. | last5 = Bertrand | first5 = Edouard | last6 = Kiss | first6 = Tamás | title = Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs | doi = 10.1093/emboj/21.11.2746 | journal = The EMBO Journal | volume = 21 | issue = 11 | pages = 2746–2756 | pmc = 126017 | year = 2002 | pmid = 12032087}} 2. ^{{Cite journal | last1 = Lestrade | first1 = Laurent | last2 = Weber | first2 = Michel J. | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | doi = 10.1093/nar/gkj002 | journal = Nucleic Acids Research | volume = 34 | issue = Supplement 1: Database Issue | pages = D158–D162 | year = 2006 | pmc = 1347365 | pmid = 16381836 | citeseerx = 10.1.1.105.7552}} 3. ^{{Cite journal | last1 = Vitali | first1 = Patrice| last2 = Royo | first2 = Hélène| last3 = Seitz | first3 = Hervé| last4 = Bachellerie | first4 = Jean‐Pierre| last5 = Hüttenhofer | first5 = Alexander| last6 = Cavaillé | first6 = Jérôme| title = Identification of 13 novel human modification guide RNAs | doi = 10.1093/nar/gkg849 | journal = Nucleic Acids Research| volume = 31 | issue = 22 | pages = 6543–6551 | date = 15 November 2003| pmid = 14602913| pmc = 275545}} 4. ^{{Cite journal | last1 = Huttenhofer | first1 = Alexander| last2 = Kiefmann | first2 = Martin| last3 = Meier-Ewert | first3 = Sebastian| last4 = O'Brien | first4 = John| last5 = Lehrach | first5 = Hans| last6 = Bachellerie | first6 = Jean-Pierre | last7 = Brosius | first7 = Jürgen| title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse| doi = 10.1093/emboj/20.11.2943 | journal = The EMBO Journal| volume = 20 | issue = 11 | pages = 2943–2953 | date = 1 June 2001| pmid = 11387227| pmc = 125495}} 5. ^{{Cite journal | last1 = Schattner | first1 = P.| last2 = Barberan-Soler | first2 = S.| last3 = Lowe | first3 = T. M.| doi = 10.1261/rna.2210406 | title = A computational screen for mammalian pseudouridylation guide H/ACA RNAs | journal = RNA| volume = 12 | issue = 1 | pages = 15–25 | date=January 2006 | pmid = 16373490| pmc = 1370881}} External links
1 : Small nuclear RNA |
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