| 词条 | Small Cajal body specific RNA 4 |
| 释义 |
| Name = Small Cajal body specific RNA 4 | image = RF00423.jpg | width = | caption = Predicted secondary structure and sequence conservation of SCARNA4 | Symbol = SCARNA4 | AltSymbols = snoACA26 | Rfam = RF00423 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; snoRNA; scaRNA | Tax_domain = Eukaryota | GO = {{GO|0006396}} {{GO|0015030}} {{GO|0005730}} | SO = {{SO|0000275}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} In molecular biology, small Cajal body specific RNA 4 (also known as ACA26) is believed to be a guide RNA of the H/ACA box class, since it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs, and is found associated with GAR1.[1] In particular, ACA26 is predicted to guide the pseudouridylation of residues U39 and U41 in U2 snRNA.[1] Such scaRNAs are a specific class of small nuclear RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[2] References1. ^1 {{Cite journal | last1 = Kiss | first1 = Arnold M. | last2 = Jády | first2 = Beáta E. | last3 = Bertrand | first3 = Edouard | last4 = Kiss | first4 = Tamás | title = Human Box H/ACA Pseudouridylation Guide RNA Machinery | doi = 10.1128/MCB.24.13.5797-5807.2004 | journal = Molecular and Cellular Biology | volume = 24 | issue = 13 | pages = 5797–5807 | pmc = 480876 | year = 2004 | pmid = 15199136}} 2. ^{{Cite journal | last1 = Darzacq | first1 = Xavier | last2 = Jády | first2 = Beáta E. | last3 = Verheggen | first3 = Céline | last4 = Kiss | first4 = Arnold M. | last5 = Bertrand | first5 = Edouard | last6 = Kiss | first6 = Tamás | title = Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs | doi = 10.1093/emboj/21.11.2746 | journal = The EMBO Journal | volume = 21 | issue = 11 | pages = 2746–2756 | pmc = 126017 | year = 2002 | pmid = 12032087}} Further reading{{refbegin}}
External links
1 : Small nuclear RNA |
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