| 词条 | Small Cajal body specific RNA 6 |
| 释义 |
| Name = Small Cajal body specific RNA 6 | image = RF00478.jpg | width = | caption = Predicted secondary structure and sequence conservation of SCARNA6 | Symbol = SCARNA6 | AltSymbols = U88 | Rfam = RF00478 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; snoRNA; scaRNA | Tax_domain = Eukaryota | GO = {{GO|0006396}} {{GO|0005730}} | SO = {{SO|0000275}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} Small Cajal body specific RNA 6 (also known as SCARNA6 or U88) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U5 spliceosomal RNA. scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12[1] U88 is found associated with both fibrillarin and Gar1p and co-localises with coilin in Cajal bodies.[1] It is an unusual guide RNA in that it is composed of both H/ACA box and a C/D box conserved domains. It is predicted to guide 2'-O-methylation of residue U41 of the U5 snRNA.[1] U88 is also closely related to other human snoRNAs scaRNA U87 and a mouse homologue MBI-46.[2] In the human genome both U88 and U87 scaRNAs share the same host gene.[1][3] References1. ^1 2 3 {{Cite journal | last1 = Darzacq | first1 = Xavier | last2 = Jády | first2 = Beáta E. | last3 = Verheggen | first3 = Céline | last4 = Kiss | first4 = Arnold M. | last5 = Bertrand | first5 = Edouard | last6 = Kiss | first6 = Tamás | title = Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs | doi = 10.1093/emboj/21.11.2746 | journal = The EMBO Journal | volume = 21 | issue = 11 | pages = 2746–2756 | pmc = 126017 | year = 2002 | pmid = 12032087}} 2. ^{{Cite journal | last1 = Huttenhofer | first1 = Alexander| last2 = Kiefmann | first2 = Martin| last3 = Meier-Ewert | first3 = Sebastian| last4 = O'Brien | first4 = John| last5 = Lehrach | first5 = Hans| last6 = Bachellerie | first6 = Jean-Pierre | last7 = Brosius | first7 = Jürgen| title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse| doi = 10.1093/emboj/20.11.2943 | journal = The EMBO Journal| volume = 20 | issue = 11 | pages = 2943–2953 | date = 1 June 2001| pmid = 11387227| pmc = 125495}} 3. ^{{Cite journal | last1 = Lestrade | first1 = Laurent | last2 = Weber | first2 = Michel J. | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | doi = 10.1093/nar/gkj002 | journal = Nucleic Acids Research | volume = 34 | issue = Supplement 1: Database Issue | pages = D158–D162 | year = 2006 | pmc = 1347365 | pmid = 16381836 | citeseerx = 10.1.1.105.7552}} External links
3 : Small nuclear RNA|Spliceosome|RNA splicing |
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