| 词条 | Small Cajal body specific RNA 8 |
| 释义 |
| Name = Small Cajal body specific RNA 8 | image = RF00286.jpg | width = | caption = Predicted secondary structure and sequence conservation of SCARNA8 | Symbol = SCARNA8 | AltSymbols = U92 | Rfam = RF00286 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; snoRNA; scaRNA | Tax_domain = Eukaryota | GO = {{GO|0006396}} {{GO|0015030}} {{GO|0005730}} | SO = {{SO|0000275}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} Small Cajal body specific RNA 8 (also known as SCARNA8 or U92) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U2 spliceosomal RNA. scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1] U92 belong to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs and is found associated with GAR1.[1] It is predicted to guide the pseudouridylation of residues U44 in U2 snRNA.[1] This snoRNA is related to the mouse H/ACA box snoRNA MBI-57.[2] References1. ^1 2 {{Cite journal | last1 = Darzacq | first1 = Xavier | last2 = Jády | first2 = Beáta E. | last3 = Verheggen | first3 = Céline | last4 = Kiss | first4 = Arnold M. | last5 = Bertrand | first5 = Edouard | last6 = Kiss | first6 = Tamás | title = Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs | doi = 10.1093/emboj/21.11.2746 | journal = The EMBO Journal | volume = 21 | issue = 11 | pages = 2746–2756 | pmc = 126017 | year = 2002 | pmid = 12032087}} 2. ^{{Cite journal | last1 = Lestrade | first1 = Laurent | last2 = Weber | first2 = Michel J. | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | doi = 10.1093/nar/gkj002 | journal = Nucleic Acids Research | volume = 34 | issue = Supplement 1: Database Issue | pages = D158–D162 | year = 2006 | pmc = 1347365 | pmid = 16381836 | citeseerx = 10.1.1.105.7552}} External links
3 : Small nuclear RNA|Spliceosome|RNA splicing |
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