| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.[1][2] Function This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA.[3] Interactions Small nuclear ribonucleoprotein D1 has been shown to interact with: - CDC5L,[4]
- CLNS1A,[5]
- DDX20,[6]
- SMN1,[7][8][9] and
- Small nuclear ribonucleoprotein D2[10][11]
References 1. ^{{cite journal | vauthors = Lehmeier T, Raker V, Hermann H, Lührmann R | title = cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 25 | pages = 12317–21 | date = Dec 1994 | pmid = 7527560 | pmc = 45428 | doi = 10.1073/pnas.91.25.12317 }}
2. ^{{cite journal | vauthors = Lehmeier T, Foulaki K, Lührmann R | title = Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5 | journal = Nucleic Acids Research | volume = 18 | issue = 22 | pages = 6475–84 | date = Nov 1990 | pmid = 1701240 | pmc = 332598 | doi = 10.1093/nar/18.22.6475 }}
3. ^{{cite web | title = Entrez Gene: SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6632| accessdate = }}
4. ^{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
5. ^{{cite journal | vauthors = Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G | title = The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins | journal = Molecular and Cellular Biology | volume = 21 | issue = 24 | pages = 8289–300 | date = Dec 2001 | pmid = 11713266 | pmc = 99994 | doi = 10.1128/MCB.21.24.8289-8300.2001 }}
6. ^{{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G | title = Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems | journal = The Journal of Cell Biology | volume = 147 | issue = 6 | pages = 1181–94 | date = Dec 1999 | pmid = 10601333 | pmc = 2168095 | doi = 10.1083/jcb.147.6.1181}}
7. ^{{cite journal | vauthors = Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U | title = Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins | journal = Human Molecular Genetics | volume = 9 | issue = 13 | pages = 1977–86 | date = Aug 2000 | pmid = 10942426 | doi = 10.1093/hmg/9.13.1977}}
8. ^{{cite journal | vauthors = Liu Q, Fischer U, Wang F, Dreyfuss G | title = The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins | journal = Cell | volume = 90 | issue = 6 | pages = 1013–21 | date = Sep 1997 | pmid = 9323129 | doi = 10.1016/s0092-8674(00)80367-0}}
9. ^{{cite journal | vauthors = Friesen WJ, Dreyfuss G | title = Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN) | journal = The Journal of Biological Chemistry | volume = 275 | issue = 34 | pages = 26370–5 | date = Aug 2000 | pmid = 10851237 | doi = 10.1074/jbc.M003299200 }}
10. ^{{cite journal | vauthors = Fury MG, Zhang W, Christodoulopoulos I, Zieve GW | title = Multiple protein: protein interactions between the snRNP common core proteins | journal = Experimental Cell Research | volume = 237 | issue = 1 | pages = 63–9 | date = Nov 1997 | pmid = 9417867 | doi = 10.1006/excr.1997.3750 }}
11. ^{{cite journal | vauthors = Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K | title = Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs | journal = Cell | volume = 96 | issue = 3 | pages = 375–87 | date = Feb 1999 | pmid = 10025403 | doi = 10.1016/s0092-8674(00)80550-4}}
Further reading {{Refbegin | 2}}- {{cite journal | vauthors = Renz M, Heim C, Bräunling O, Czichos A, Wieland C, Seelig HP | title = Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases | journal = Clinical Chemistry | volume = 35 | issue = 9 | pages = 1861–3 | date = Sep 1989 | pmid = 2528429 | doi = }}
- {{cite journal | vauthors = Rokeach LA, Haselby JA, Hoch SO | title = Molecular cloning of a cDNA encoding the human Sm-D autoantigen | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 85 | issue = 13 | pages = 4832–6 | date = Jul 1988 | pmid = 3260384 | pmc = 280530 | doi = 10.1073/pnas.85.13.4832 }}
- {{cite journal | vauthors = Sun D, Ou YC, Hoch SO | title = Analysis of genes for human snRNP Sm-D1 protein and identification of the promoter sequence which shows segmental homology to the promoters of Sm-E and U1 snRNA genes | journal = Gene | volume = 189 | issue = 2 | pages = 245–54 | date = Apr 1997 | pmid = 9168134 | doi = 10.1016/S0378-1119(96)00858-X }}
- {{cite journal | vauthors = Liu Q, Fischer U, Wang F, Dreyfuss G | title = The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins | journal = Cell | volume = 90 | issue = 6 | pages = 1013–21 | date = Sep 1997 | pmid = 9323129 | doi = 10.1016/S0092-8674(00)80367-0 }}
- {{cite journal | vauthors = Fury MG, Zhang W, Christodoulopoulos I, Zieve GW | title = Multiple protein: protein interactions between the snRNP common core proteins | journal = Experimental Cell Research | volume = 237 | issue = 1 | pages = 63–9 | date = Nov 1997 | pmid = 9417867 | doi = 10.1006/excr.1997.3750 }}
- {{cite journal | vauthors = Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K | title = Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs | journal = Cell | volume = 96 | issue = 3 | pages = 375–87 | date = Feb 1999 | pmid = 10025403 | doi = 10.1016/S0092-8674(00)80550-4 }}
- {{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G | title = Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems | journal = The Journal of Cell Biology | volume = 147 | issue = 6 | pages = 1181–94 | date = Dec 1999 | pmid = 10601333 | pmc = 2168095 | doi = 10.1083/jcb.147.6.1181 }}
- {{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G | title = Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli | journal = The Journal of Cell Biology | volume = 148 | issue = 6 | pages = 1177–86 | date = Mar 2000 | pmid = 10725331 | pmc = 2174312 | doi = 10.1083/jcb.148.6.1177 }}
- {{cite journal | vauthors = Mammoto A, Sasaki T, Kim Y, Takai Y | title = Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking | journal = The Journal of Biological Chemistry | volume = 275 | issue = 18 | pages = 13167–70 | date = May 2000 | pmid = 10747849 | doi = 10.1074/jbc.C000096200 }}
- {{cite journal | vauthors = Brahms H, Raymackers J, Union A, de Keyser F, Meheus L, Lührmann R | title = The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 17122–9 | date = Jun 2000 | pmid = 10747894 | doi = 10.1074/jbc.M000300200 }}
- {{cite journal | vauthors = Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U | title = Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins | journal = Human Molecular Genetics | volume = 9 | issue = 13 | pages = 1977–86 | date = Aug 2000 | pmid = 10942426 | doi = 10.1093/hmg/9.13.1977 }}
- {{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
- {{cite journal | vauthors = Selenko P, Sprangers R, Stier G, Bühler D, Fischer U, Sattler M | title = SMN tudor domain structure and its interaction with the Sm proteins | journal = Nature Structural Biology | volume = 8 | issue = 1 | pages = 27–31 | date = Jan 2001 | pmid = 11135666 | doi = 10.1038/83014 }}
- {{cite journal | vauthors = Urlaub H, Raker VA, Kostka S, Lührmann R | title = Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure | journal = The EMBO Journal | volume = 20 | issue = 1-2 | pages = 187–96 | date = Jan 2001 | pmid = 11226169 | pmc = 140196 | doi = 10.1093/emboj/20.1.187 }}
- {{cite journal | vauthors = Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G | title = SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets | journal = Molecular Cell | volume = 7 | issue = 5 | pages = 1111–7 | date = May 2001 | pmid = 11389857 | doi = 10.1016/S1097-2765(01)00244-1 }}
- {{cite journal | vauthors = Park JW, Voss PG, Grabski S, Wang JL, Patterson RJ | title = Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein | journal = Nucleic Acids Research | volume = 29 | issue = 17 | pages = 3595–602 | date = Sep 2001 | pmid = 11522829 | pmc = 55878 | doi = 10.1093/nar/29.17.3595 }}
- {{cite journal | vauthors = Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G | title = The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins | journal = Molecular and Cellular Biology | volume = 21 | issue = 24 | pages = 8289–300 | date = Dec 2001 | pmid = 11713266 | pmc = 99994 | doi = 10.1128/MCB.21.24.8289-8300.2001 }}
- {{cite journal | vauthors = Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G | title = Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins | journal = The Journal of Biological Chemistry | volume = 277 | issue = 7 | pages = 5631–6 | date = Feb 2002 | pmid = 11714716 | doi = 10.1074/jbc.M109448200 }}
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